Beronius Anna, Vandenberg Laura N
Department of Environmental Science and Analytical Chemistry, Stockholm University, Stockholm, Sweden.
Department of Environmental Health Sciences, University of Massachusetts Amherst School of Public Health & Health Sciences, 149B Goessmann, 686 N. Pleasant Street, Amherst, MA, 01003, USA.
Rev Endocr Metab Disord. 2015 Dec;16(4):273-87. doi: 10.1007/s11154-016-9334-7.
The possibility that endocrine disrupting chemicals (EDCs) in our environment contribute to hormonally related effects and diseases observed in human and wildlife populations has caused concern among decision makers and researchers alike. EDCs challenge principles traditionally applied in chemical risk assessment and the identification and assessment of these compounds has been a much debated topic during the last decade. State of the science reports and risk assessments of potential EDCs have been criticized for not using systematic and transparent approaches in the evaluation of evidence. In the fields of medicine and health care, systematic review methodologies have been developed and used to enable objectivity and transparency in the evaluation of scientific evidence for decision making. Lately, such approaches have also been promoted for use in the environmental health sciences and risk assessment of chemicals. Systematic review approaches could provide a tool for improving the evaluation of evidence for decision making regarding EDCs, e.g. by enabling systematic and transparent use of academic research data in this process. In this review we discuss the advantages and challenges of applying systematic review methodology in the identification and assessment of EDCs.
我们环境中的内分泌干扰化学物质（EDCs）可能导致人类和野生动物种群中出现与激素相关的影响和疾病，这一可能性已引起决策者和研究人员的关注。EDCs对传统应用于化学风险评估的原则构成挑战，在过去十年中，这些化合物的识别和评估一直是一个备受争议的话题。潜在EDCs的科学现状报告和风险评估因在证据评估中未采用系统和透明的方法而受到批评。在医学和医疗保健领域，已经开发并使用了系统评价方法，以在评估科学证据以供决策时实现客观性和透明度。最近，此类方法也被推广用于环境卫生科学和化学品风险评估。系统评价方法可以提供一种工具，用于改进关于EDCs决策的证据评估，例如通过在此过程中实现对学术研究数据的系统和透明使用。在本综述中，我们讨论了在EDCs的识别和评估中应用系统评价方法的优点和挑战。
