Stewart A G, Beart P M
Lung health Research Centre, Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Australia.
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.
Br J Pharmacol. 2016 Feb;173(4):631-4. doi: 10.1111/bph.13389.
The continued focus of attention on the diversity of mechanisms underpinning inflammation has improved our understanding of the potential to target specific pathways in the inflammatory network to achieve meaningful therapeutic gains. In this themed issue of the British Journal of Pharmacology our scope was deliberately broad, ranging across both acute and chronic disease in various organs. Pro- and anti-inflammatory mechanisms receive attention as does the phenotype of macrophages. Whilst the manifestations of neuro-inflammation are less obvious than those in peripheral tissues, central innate and adaptive immunity in brain and the M1/M2 phenotypes of microglia are topics of special interest. The contributions to the inflammatory milieu of cytokines, chemokines and associated signalling cascades are considered. Overall, the coverage herein advances the basic science underpinning our understanding of inflammation and emphasizes its importance in different pathologies.
对炎症潜在机制多样性的持续关注，加深了我们对靶向炎症网络中特定途径以获得有意义治疗效果可能性的理解。在本期《英国药理学杂志》主题特刊中，我们的范围有意设定得很宽泛，涵盖了各个器官的急性和慢性疾病。促炎和抗炎机制以及巨噬细胞的表型都受到了关注。虽然神经炎症的表现不如外周组织明显，但大脑中的中枢固有免疫和适应性免疫以及小胶质细胞的M1/M2表型是特别受关注的主题。文中还探讨了细胞因子、趋化因子及相关信号级联反应对炎症环境的影响。总体而言，本文的内容推进了支撑我们对炎症理解的基础科学，并强调了其在不同病理状况中的重要性。
