Jairajpuri Deeba S, Almawi Wassim Y
Department of Medical Biochemistry, Arabian Gulf University, Manama 26671, Kingdom of Bahrain.
Mol Med Rep. 2016 Mar;13(3):2351-8. doi: 10.3892/mmr.2016.4846. Epub 2016 Feb 2.
Pre-eclampsia (PE), a pregnancy complication, is a leading cause of maternal and fetal morbidity and mortality. Although its exact etiology and pathogenesis remain elusive, PE results from an interaction of inherited and non‑inherited factors. The clinical symptoms of PE appear post‑mid‑stage of gestation and, at present, there are no early signs/markers for its onset and progression. MicroRNAs function as gene regulators, and are involved in development and pathology. A burgeoning number of studies have highlighted microRNAs as potential biomarkers for minimal invasive assessment. However, it remains a matter of debate as to which microRNA type is involved in PE onset and progression, as well as the clinical utility of testing for these species. In the present review, we have summarized the latest findings on the association of PE with the aberrant expression of placental microRNAs; in particular, those that are detectable in the blood. The current understanding of the mechanisms of microRNA‑target gene interactions that underpin the involvement of microRNAs in the pathogenesis of PE is also discussed.
子痫前期（PE）是一种妊娠并发症，是孕产妇和胎儿发病及死亡的主要原因。尽管其确切病因和发病机制仍不清楚，但PE是由遗传和非遗传因素相互作用引起的。PE的临床症状出现在妊娠中期之后，目前尚无其发病和进展的早期迹象/标志物。微小RNA作为基因调节因子，参与发育和病理过程。越来越多的研究强调微小RNA作为微创评估的潜在生物标志物。然而，关于哪种类型的微小RNA参与PE的发病和进展以及检测这些微小RNA的临床效用仍存在争议。在本综述中，我们总结了关于PE与胎盘微小RNA异常表达之间关联的最新发现；特别是那些在血液中可检测到的微小RNA。还讨论了目前对微小RNA-靶基因相互作用机制的理解，这些机制是微小RNA参与PE发病机制的基础。
