Ahn Ji Sook, Van Lancker Sidtis Diana, Sidtis John J
Department of Communicative Sciences and Disorders, New York University, New York, NY.
Brain and Behavior Laboratory, Geriatrics Division, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY.
J Med Speech Lang Pathol. 2014;21(3):179-186.
The present study examined pausing patterns in spontaneous speech as a measure of the effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) on parkinsonian speech. Pauses reflect various aspects of speech and language processes, including motor initiation and linguistic planning. Relatively little attention has been given to pauses in determining the effect of STN-DBS. An examination of pausing may be helpful to understanding how this form of therapy affects these behaviors. Seven individuals with Parkinson's disease who received surgery for bilateral STN-DBS participated. Spontaneous speech samples were elicited in both the ON and OFF STN-DBS condition. Findings indicated that long pauses (250-3000 ms) in spontaneous speech were significantly shorter and more frequent in the STN-DBS ON condition. Furthermore, the proportion of nonlinguistic boundary pauses was significantly greater with stimulation. The findings support previous studies suggesting that speech motor control and lexical retrieval may be affected by STN-DBS.
本研究检测了自发言语中的停顿模式，以此作为衡量丘脑底核（STN）深部脑刺激（DBS）对帕金森病言语影响的一项指标。停顿反映了言语和语言过程的各个方面，包括运动启动和语言规划。在确定STN-DBS的效果时，停顿相对较少受到关注。对停顿的研究可能有助于理解这种治疗形式如何影响这些行为。七名接受双侧STN-DBS手术的帕金森病患者参与了研究。在STN-DBS开启和关闭状态下均采集了自发言语样本。研究结果表明，在STN-DBS开启状态下，自发言语中的长停顿（250 - 3000毫秒）明显更短且更频繁。此外，刺激时非语言边界停顿的比例显著更高。这些发现支持了先前的研究，表明言语运动控制和词汇检索可能受到STN-DBS的影响。
