Lee Young In, Lee Minseok, Lee Sewon, Kim Do Young
Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Leeand Skin Clinic, Seoul, Korea.
Ann Dermatol. 2019 Apr;31(2):217-220. doi: 10.5021/ad.2019.31.2.217. Epub 2019 Feb 28.
Despite multiple possible side effects, mesotherapy with a diverse mixture of unapproved products has been performed for the treatment of hair loss. In this case report, we present a rare case of permanent hair loss due to an allergic reaction from a mesotherapy mixture including triamcinolone acetonide. The patient showed a positive intradermal allergic skin test result for triamcinolone and therefore was diagnosed with scarring alopecia due to delayed type IV hypersensitivity to corticosteroid. This case study suggests that dermatologists should always be fully aware that both IgE-mediated and non-IgE-mediated hypersensitivity reactions from the corticosteroids as well as their mesotherapy excipients are possible in an effort to prevent irreversible adverse event from the mesotherapy.
尽管存在多种可能的副作用,但使用多种未经批准的产品进行的中胚层疗法已被用于治疗脱发。在本病例报告中,我们展示了一例罕见的永久性脱发病例,该病例是由于含有曲安奈德的中胚层疗法混合物引起的过敏反应所致。患者对曲安奈德的皮内过敏皮肤试验结果呈阳性,因此被诊断为因对皮质类固醇的IV型迟发型超敏反应导致的瘢痕性脱发。本病例研究表明,皮肤科医生应始终充分意识到皮质类固醇及其中胚层疗法辅料可能引发IgE介导和非IgE介导的超敏反应,以努力预防中胚层疗法导致的不可逆不良事件。