一种基于竞争性配位的二氧化铈纳米线-脱氧核糖核酸纳米传感器：在活细胞和体内快速、选择性地检测过氧化氢
A competitive coordination-based CeO2 nanowire-DNA nanosensor: fast and selective detection of hydrogen peroxide in living cells and in vivo.
作者信息
Gao Wen, Wei Xueping, Wang Xuejun, Cui Guanwei, Liu Zhenhua, Tang Bo
机构信息
College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, P. R. China.
Shandong Center for Disease Control and Prevention, Jinan 250014, P. R. China.
出版信息
Chem Commun (Camb). 2016 Mar 4;52(18):3643-6. doi: 10.1039/c6cc00112b.
A competitive coordination-based hydrogen peroxide (H2O2) nanosensor is constructed by the assembly of FAM-tagged single-strand (ss) DNA on cerium oxide nanowires (CeO2 NWs). This fluorescent nanosensor is capable of rapidly and selectively tracking H2O2 within living cells, as well as directly visualizing H2O2 generated by wound-induced oxidative damage in zebrafish larvae.
通过将羧基荧光素（FAM）标记的单链（ss）DNA组装在氧化铈纳米线（CeO2 NWs）上，构建了一种基于竞争性配位的过氧化氢（H2O2）纳米传感器。这种荧光纳米传感器能够在活细胞内快速、选择性地追踪H2O2，还能直接观察斑马鱼幼虫伤口诱导的氧化损伤所产生的H2O2。
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