遗传变异与膀胱输尿管反流后遗症。
Genetic Variations in Vesicoureteral Reflux Sequelae.
机构信息
Innate Immunity Translational Research Center, Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA.
Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH 43205, USA.
出版信息
Pathogens. 2016 Feb 2;5(1):14. doi: 10.3390/pathogens5010014.
Urinary tract infections (UTI) are a common condition in children. Vesicoureteral reflux (VUR) represents a common associated condition with childhood UTI. UTI susceptibility appears to have a genetic component based on family and UTI cohort studies. Targeted analysis of innate immune system genetic variations indicate that these variations are important in UTI susceptibility. In this overview, we discuss how current cohorts and genetic strategies can be implemented to discover new susceptibility loci in patients with UTI.
尿路感染（UTI）是儿童的常见病症。膀胱输尿管反流（VUR）是儿童 UTI 的常见相关病症。基于家族和 UTI 队列研究，UTI 的易感性似乎具有遗传成分。针对固有免疫系统遗传变异的靶向分析表明，这些变异在 UTI 易感性中很重要。在这篇综述中，我们讨论了如何实施当前的队列和遗传策略来发现 UTI 患者的新易感性位点。
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