Xu Ye-Qiong, Jiang Ting-Wang, Cui Yan-Hong, Zhao Yi-Lin, Qiu Li-Qing
Molecular Laboratory, Changshu Medicine Examination Institute, Suzhou, Jiangsu, China.
Department of Flow Cytometry, Changshu Medicine Examination Institute, Suzhou, Jiangsu, China.
J Surg Res. 2016 Mar;201(1):188-95. doi: 10.1016/j.jss.2015.10.039. Epub 2015 Nov 5.
Previous studies have shown a link between the ABO blood groups and prognoses for several types of malignancies. However, little is known about the relationship between the ABO blood groups and prognosis in patients with gastric cancer (GC). The aim of this study was to investigate the prognostic performance of ABO blood groups in patients with GC.
A total of 1412 GC patients who had undergone curative intent surgery between January 2005 and January 2010 participated in the present study. A prognostic nomogram was constructed to improve the predictive capacity for patients with gastrectomy using R software, and its predictive accuracy was determined by the concordance index (c-index).
The median follow-up period of the 1412 GC patients was 44 mo with 809 alive. Non-AB blood groups were associated with significantly decreased overall survival in GC patients (hazard ratio = 2.59; 95% confidence interval = 1.74-3.86, P < 0.001), but patients in the group AB had a better prognosis than those in the non-AB blood groups. Meanwhile, group A had the worst prognosis among all the blood groups (hazard ratio = 3.14; 95% confidence interval = 2.09-4.72; P < 0.001). In addition, our constructed nomogram, superior to that of the traditional AJCC stage system (c-index: 0.69), could more accurately predict overall survival (c-index: 0.78) in GC patients who had undergone gastrectomy.
The blood group AB is a favorable prognostic factor for GC patients, but the blood group A is an adverse prognostic factor for patients with gastrectomy. Further prospective studies are warranted to confirm this relationship.
先前的研究表明ABO血型与几种恶性肿瘤的预后之间存在联系。然而，关于ABO血型与胃癌（GC）患者预后之间的关系却知之甚少。本研究的目的是调查ABO血型对GC患者的预后表现。
共有1412例在2005年1月至2010年1月期间接受了根治性手术的GC患者参与了本研究。使用R软件构建了一个预后列线图，以提高对胃切除术患者的预测能力，并通过一致性指数（c指数）确定其预测准确性。
1412例GC患者的中位随访期为44个月，809例存活。非AB血型与GC患者的总生存期显著降低相关（风险比=2.59；95%置信区间=1.74-3.86，P<0.001），但AB血型组患者的预后优于非AB血型组患者。同时，A组在所有血型组中的预后最差（风险比=3.14；95%置信区间=2.09-4.72；P<0.001）。此外，我们构建的列线图优于传统的美国癌症联合委员会（AJCC）分期系统（c指数：0.69），能够更准确地预测接受胃切除术的GC患者的总生存期（c指数：0.78）。
AB血型是GC患者的一个有利预后因素，但A血型是胃切除术患者的一个不利预后因素。有必要进行进一步的前瞻性研究来证实这种关系。
