Bruner S D, Jobin C
Department of Chemistry, University of Florida, Gainesville, Florida, USA.
Department of Medicine, University of Florida, Gainesville, Florida, USA.
Clin Pharmacol Ther. 2016 Jun;99(6):585-7. doi: 10.1002/cpt.348. Epub 2016 Feb 19.
Trillions of bacteria inhabit our intestine, forming a community called the microbiota, whose contributions are essential to maintain host homeostasis. Disruption of this normal microbial-host communication network has deleterious consequences for the host and is associated with intestinal pathologies such as inflammatory bowel diseases (IBD) and colorectal cancer (CRC). Here we present key concepts and mechanisms by which bacteria may participate in intestinal pathology, and discuss possible means to therapeutically target the microbiome.
数万亿细菌栖息在我们的肠道中，形成一个称为微生物群的群落，其作用对于维持宿主的内环境稳定至关重要。这种正常的微生物与宿主通讯网络的破坏会对宿主产生有害影响，并与肠道疾病如炎症性肠病（IBD）和结直肠癌（CRC）相关。在这里，我们介绍了细菌可能参与肠道病理的关键概念和机制，并讨论了针对微生物群进行治疗的可能方法。
