Angoorani Pooneh, Ejtahed Hanieh-Sadat, Mirmiran Parvin, Mirzaei Sahar, Azizi Fereidoun
a Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran ;
b Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences , Tehran , Iran ;
Int J Food Sci Nutr. 2016;67(2):170-6. doi: 10.3109/09637486.2015.1137889. Epub 2016 Feb 5.
Metabolic syndrome (MetS) is a complex disorder which has become one of the major public health challenges worldwide. This study was conducted to evaluate the association between dietary advanced glycation end products (AGEs) and risk of MetS and its components. This cross-sectional study was conducted in a representative sample of 5848 adults, aged 19-70 years. Daily consumption of carboxymethyl lysine, a major type of AGEs, was determined using a validated semi-quantitative food frequency questionnaire. Across increasing trend of AGEs consumption, the percentage of fat intake increased and that of carbohydrate significantly decreased (p < 0.001). Subjects in the highest (>10,506 kU/d) compared to the lowest (<6673 kU/d) quartile category of AGEs had higher risk of abdominal obesity (OR: 1.19, 95% CI: 1.01-1.39) and hypertriglyceridemia (OR: 1.26, 95% CI: 1.07-1.49). Therefore, recommendation on restriction of AGEs intake could be a practical approach to prevent metabolic abnormalities.
代谢综合征（MetS）是一种复杂的病症，已成为全球主要的公共卫生挑战之一。本研究旨在评估膳食晚期糖基化终产物（AGEs）与代谢综合征及其组分风险之间的关联。这项横断面研究在5848名年龄在19至70岁的成年人代表性样本中进行。使用经过验证的半定量食物频率问卷来确定主要类型AGEs之一的羧甲基赖氨酸的每日摄入量。随着AGEs摄入量的增加趋势，脂肪摄入量的百分比增加，而碳水化合物的百分比显著下降（p < 0.001）。与最低（<6673 kU/d）四分位数类别相比，最高（>10,506 kU/d）AGEs四分位数类别的受试者腹部肥胖风险更高（OR：1.19，95% CI：1.01 - 1.39）和高甘油三酯血症风险更高（OR：1.26，95% CI：1.07 - 1.49）。因此，建议限制AGEs摄入量可能是预防代谢异常的一种实用方法。
