Doppler Kathrin, Schütt Morten, Sommer Claudia
Department of Neurology, University Hospital Würzburg, Würzburg, Germany
Department of Internal Medicine I, University Hospital Lübeck, Lübeck, Germany.
Cephalalgia. 2016 Dec;36(14):1379-1384. doi: 10.1177/0333102416630592. Epub 2016 Feb 6.
Idiopathic intracranial hypertension is characterized by increased intracranial pressure. Its pathogenesis is largely unknown. Aquaporins may play a role in the homeostasis of cerebrospinal fluid.
We aimed to elucidate the role of aquaporins in idiopathic intracranial hypertension by measuring the level of aquaporin-1 and aquaporin-4 in the cerebrospinal fluid and plasma of 28 patients and 29 controls by enzyme-linked immunosorbent assay. The adipokines leptin and retinol-binding protein 4 were also measured.
We found a reduction in aquaporin-4 in the cerebrospinal fluid of patients. Leptin levels were increased in the cerebrospinal fluid and plasma of patients and were correlated with weight, body mass index and body fat. There was no difference between patients and controls in the levels of aquaporin-1 and retinol-binding protein 4.
Our data suggest that an imbalance of aquaporin-4 in the cerebrospinal fluid of patients with idiopathic intracranial hypertension may contribute to the pathogenesis of this disorder.
特发性颅内高压的特征是颅内压升高。其发病机制在很大程度上尚不清楚。水通道蛋白可能在脑脊液的稳态中起作用。
我们旨在通过酶联免疫吸附测定法测量28例患者和29例对照者脑脊液和血浆中水通道蛋白-1和水通道蛋白-4的水平，以阐明水通道蛋白在特发性颅内高压中的作用。还测量了脂肪因子瘦素和视黄醇结合蛋白4。
我们发现患者脑脊液中水通道蛋白-4减少。患者脑脊液和血浆中的瘦素水平升高，且与体重、体重指数和体脂相关。患者和对照者在水通道蛋白-1和视黄醇结合蛋白4水平上没有差异。
我们的数据表明，特发性颅内高压患者脑脊液中水通道蛋白-4的失衡可能导致该疾病的发病机制。
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