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患与未患特发性颅内高压患者脑脊液中的维生素A

Vitamin A in the cerebrospinal fluid of patients with and without idiopathic intracranial hypertension.

作者信息

Warner Judith E A, Bernstein Paul S, Yemelyanov Alexander, Alder Stephen C, Farnsworth Steven T, Digre Kathleen B

机构信息

Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah Health Sciences Center, 50 North Medical Drive, Salt Lake City, UT 84132, USA.

出版信息

Ann Neurol. 2002 Nov;52(5):647-50. doi: 10.1002/ana.10377.

Abstract

We quantified vitamin A in the cerebrospinal fluid of patients with idiopathic intracranial hypertension, elevated intracranial pressure of other causes and normal intracranial pressure. Vitamin A could be detected by high-pressure liquid chromatography in most of the specimens. There was a significantly higher level of vitamin A in the cerebrospinal fluid of some patients with idiopathic intracranial hypertension. Vitamin A toxicity may play a role in the pathogenesis of idiopathic intracranial hypertension.

摘要

我们对特发性颅内高压、其他原因引起的颅内压升高以及颅内压正常的患者脑脊液中的维生素A进行了定量分析。大多数样本中可通过高压液相色谱法检测到维生素A。部分特发性颅内高压患者的脑脊液中维生素A水平显著更高。维生素A毒性可能在特发性颅内高压的发病机制中起作用。

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