Tabassi Abdolreza, Salmasi Amirali Hassanzadeh, Jalali Mahmoud
Neuro-ophthalmology Clinic, School of Public Health, Tehran University of Medical Sciences, Iran.
Neurology. 2005 Jun 14;64(11):1893-6. doi: 10.1212/01.WNL.0000163556.31080.98.
Elevated serum retinol, CSF retinol, and serum retinol binding protein (RBP) levels have been found in some patients with idiopathic intracranial hypertension (IIH), but serum and CSF retinol levels have not been studied in matched serum and CSF samples in patients with IIH.
To determine whether serum and CSF vitamin A concentrations are associated with IIH.
The serum and CSF retinol concentrations were prospectively assessed in 20 patients with IIH and 20 control subjects.
CSF retinol concentration was higher in the patient group (median 575.91 nM) vs the control group (median 63.35 nM) (p < 0.05). There was no difference in serum retinol levels between control subjects (median 896.51 nM) and patients (median 1,002.62 nM) (p = 0.10). There was an association between higher vitamin A levels (> 250 nM) and IIH (p = 0.039). There was a correlation between CSF and serum retinol levels in patients (r = 0.82) and control subjects (r = 0.66).
Elevated CSF retinol concentration is associated with idiopathic intracranial hypertension (IIH), but serum retinol level is not associated with IIH.
在一些特发性颅内高压（IIH）患者中发现血清视黄醇、脑脊液视黄醇和血清视黄醇结合蛋白（RBP）水平升高，但尚未对IIH患者匹配的血清和脑脊液样本中的血清和脑脊液视黄醇水平进行研究。
确定血清和脑脊液维生素A浓度是否与IIH相关。
前瞻性评估20例IIH患者和20例对照者的血清和脑脊液视黄醇浓度。
患者组脑脊液视黄醇浓度（中位数575.91 nM）高于对照组（中位数63.35 nM）（p < 0.05）。对照组（中位数896.51 nM）和患者（中位数1,002.62 nM）的血清视黄醇水平无差异（p = 0.10）。较高的维生素A水平（> 250 nM）与IIH之间存在关联（p = 0.039）。患者（r = 0.82）和对照者（r = 0.66）的脑脊液和血清视黄醇水平之间存在相关性。
脑脊液视黄醇浓度升高与特发性颅内高压（IIH）相关，但血清视黄醇水平与IIH无关。
