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在一个转化性大动物模型中,关节镜下前交叉韧带重建采用悬吊固定与干涉螺钉固定的比较

Suspensory Versus Interference Screw Fixation for Arthroscopic Anterior Cruciate Ligament Reconstruction in a Translational Large-Animal Model.

作者信息

Smith Patrick A, Stannard James P, Pfeiffer Ferris M, Kuroki Keiichi, Bozynski Chantelle C, Cook James L

机构信息

Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri, U.S.A.; Columbia Orthopaedic Group, Columbia, Missouri, U.S.A.

Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri, U.S.A.; Comparative Orthopaedic Laboratory, Columbia, Missouri, U.S.A.

出版信息

Arthroscopy. 2016 Jun;32(6):1086-97. doi: 10.1016/j.arthro.2015.11.026. Epub 2016 Feb 4.

Abstract

PURPOSE

To compare all-inside cortical-button suspensory fixation in sockets versus interference screw fixation in tunnels with respect to clinical, histologic, and biomechanical assessments of all-soft tissue (AST) tendon autografts used for anterior cruciate ligament (ACL) reconstruction in a canine model.

METHODS

By use of a validated "hybrid" double-bundle ACL reconstruction technique (reconstruction of the anteromedial bundle with preservation of the native posterolateral bundle), dogs were randomly assigned to undergo either suspensory fixation in sockets (n = 6) or interference screw fixation in tunnels (n = 6). Contralateral knees were used as nonoperated controls (n = 12). Quadrupled extensor tendon autografts were used for both ACL reconstruction groups. Dogs were assessed radiographically and functionally and humanely euthanized at 12 weeks after surgery for arthroscopic, gross, biomechanical, and histologic assessments.

RESULTS

Histologic assessments showed significantly (P = .018) better graft incorporation with 4-zone direct healing to bone for the grafts using suspensory fixation in sockets (16.3 ± 1.5) compared with the grafts using interference screw fixation in tunnels (14.2 ± 2.1). Furthermore, graft healing to bone was significantly better at the aperture (P = .05) and mid-socket (P = .01) location for the group that underwent suspensory fixation in sockets (16.1 ± 1.8 and 16.4 ± 1.9, respectively).

CONCLUSIONS

Suspensory fixation of AST grafts in sockets was associated with superior tendon-to-bone healing compared with interference screw fixation in tunnels, with 4-zone direct graft healing to bone seen for femoral and tibial sockets only in the suspensory-fixation group. Biomechanical properties were similar between groups.

CLINICAL RELEVANCE

These data provide evidence suggesting that an all-inside ACL reconstruction technique using adjustable-loop cortical-button suspensory fixation in bone sockets has potential clinical advantages for ACL reconstruction using AST grafts.

摘要

目的

在犬类模型中,就用于前交叉韧带(ACL)重建的全软组织(AST)自体移植物的临床、组织学和生物力学评估,比较骨隧道内皮质纽扣悬吊固定与隧道内挤压螺钉固定。

方法

采用经验证的“混合”双束ACL重建技术(重建前内侧束并保留天然后外侧束),将犬随机分为两组,分别接受骨隧道内悬吊固定(n = 6)或隧道内挤压螺钉固定(n = 6)。对侧膝关节用作非手术对照(n = 12)。两组ACL重建均使用四倍体伸肌腱自体移植物。术后12周对犬进行放射学和功能评估,并实施安乐死,以便进行关节镜、大体、生物力学和组织学评估。

结果

组织学评估显示,与采用隧道内挤压螺钉固定的移植物(14.2±2.1)相比,采用骨隧道内悬吊固定的移植物(16.3±1.5)与骨的4区直接愈合情况明显更好(P = 0.018)。此外,对于接受骨隧道内悬吊固定的组,移植物在骨隧道开口处(P = 0.05)和骨隧道中部(P = 0.01)位置与骨的愈合明显更好(分别为16.1±1.8和16.4±1.9)。

结论

与隧道内挤压螺钉固定相比,骨隧道内AST移植物的悬吊固定与更好的腱骨愈合相关,仅在悬吊固定组的股骨和胫骨隧道中可见移植物与骨的4区直接愈合。两组之间的生物力学特性相似。

临床意义

这些数据表明,在骨隧道中使用可调节环皮质纽扣悬吊固定的全内置ACL重建技术,在使用AST移植物进行ACL重建方面具有潜在的临床优势。

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