延伸因子EF-1α基因剂量改变酿酒酵母的翻译保真度。
Elongation factor EF-1 alpha gene dosage alters translational fidelity in Saccharomyces cerevisiae.
作者信息
Song J M, Picologlou S, Grant C M, Firoozan M, Tuite M F, Liebman S
机构信息
Department of Biological Sciences, University of Illinois, Chicago 60680.
出版信息
Mol Cell Biol. 1989 Oct;9(10):4571-5. doi: 10.1128/mcb.9.10.4571-4575.1989.
Abstract
Changes in the dosage of genes encoding elongation factor EF-1 alpha were shown to cause parallel changes in the misreading of nonsense codons. Higher amounts of EF-1 alpha were correlated with increased nonsense suppression, suggesting that the level of EF-1 alpha is critically involved in translational fidelity.
摘要
编码延伸因子EF-1α的基因剂量变化被证明会导致无义密码子错读的平行变化。较高水平的EF-1α与增加的无义抑制相关，这表明EF-1α的水平在翻译保真度中起着关键作用。
Zotero 插件