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延伸因子EF-1α基因剂量改变酿酒酵母的翻译保真度。

Elongation factor EF-1 alpha gene dosage alters translational fidelity in Saccharomyces cerevisiae.

作者信息

Song J M, Picologlou S, Grant C M, Firoozan M, Tuite M F, Liebman S

机构信息

Department of Biological Sciences, University of Illinois, Chicago 60680.

出版信息

Mol Cell Biol. 1989 Oct;9(10):4571-5. doi: 10.1128/mcb.9.10.4571-4575.1989.

DOI:10.1128/mcb.9.10.4571-4575.1989
PMID:2685557
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC362547/
Abstract

Changes in the dosage of genes encoding elongation factor EF-1 alpha were shown to cause parallel changes in the misreading of nonsense codons. Higher amounts of EF-1 alpha were correlated with increased nonsense suppression, suggesting that the level of EF-1 alpha is critically involved in translational fidelity.

摘要

编码延伸因子EF-1α的基因剂量变化被证明会导致无义密码子错读的平行变化。较高水平的EF-1α与增加的无义抑制相关，这表明EF-1α的水平在翻译保真度中起着关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95fc/362547/c588b42e86d5/molcellb00058-0466-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95fc/362547/544379a0353a/molcellb00058-0464-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95fc/362547/25ccecfa5693/molcellb00058-0465-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95fc/362547/c588b42e86d5/molcellb00058-0466-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95fc/362547/544379a0353a/molcellb00058-0464-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95fc/362547/25ccecfa5693/molcellb00058-0465-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95fc/362547/c588b42e86d5/molcellb00058-0466-a.jpg

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本文引用的文献

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2
Phosphorylation of elongation factor 1 in polyribosome fraction of rabbit reticulocytes.兔网织红细胞多核糖体组分中延伸因子1的磷酸化作用
FEBS Lett. 1984 Oct 29;176(2):401-5. doi: 10.1016/0014-5793(84)81206-5.
3
Identification of two genes coding for the translation elongation factor EF-1 alpha of S. cerevisiae.酿酒酵母翻译延伸因子EF-1α编码的两个基因的鉴定。
酿酒酵母中蛋白质合成的机制与调控
Genetics. 2016 May;203(1):65-107. doi: 10.1534/genetics.115.186221.
4
Modulation of efficiency of translation termination in Saccharomyces cerevisiae.酿酒酵母中翻译终止效率的调控
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5
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RNA. 2005 Nov;11(11):1710-8. doi: 10.1261/rna.2131605. Epub 2005 Sep 21.
6
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7
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Overexpression of translation elongation factor 1A affects the organization and function of the actin cytoskeleton in yeast.翻译延伸因子1A的过表达影响酵母中肌动蛋白细胞骨架的组织和功能。
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