一种作用于酵母中全能抑制子的抗抑制子。
An antisuppressor that acts on omnipotent suppressors in yeast.
作者信息
Liebman S W, Cavenagh M
出版信息
Genetics. 1980 May;95(1):49-61. doi: 10.1093/genetics/95.1.49.
Abstract
Six partially dominant antisuppressors were obtained that reduce the efficiency of two omnipotent yeast suppressors, sup45 and sup35, thought to be ribosomal ambiguity mutations. Each of these six antisuppressors was shown to fall within a single Mendelian locus, named asu9. The asu9 mutations are specific for omnipotent suppressors; they have no effect on several dominant tRNA-like suppressors. In the absence of suppressors, asu9 causes sensitivity to the aminoglycoside antibiotic, paromomycin. The properties of asu9 are consistent with the hypothesis that asu9 alters yeast ribosomal proteins.
摘要
获得了六个部分显性的反抑制基因，它们降低了两种全能酵母抑制基因sup45和sup35的效率，这两种抑制基因被认为是核糖体模糊性突变。这六个反抑制基因中的每一个都被证明位于一个单一的孟德尔位点内，命名为asu9。asu9突变对全能抑制基因具有特异性；它们对几种显性的tRNA样抑制基因没有影响。在没有抑制基因的情况下，asu9会导致对氨基糖苷类抗生素巴龙霉素敏感。asu9的特性与asu9改变酵母核糖体蛋白的假设一致。
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