Unit of Health-Care Epidemiology, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK; Department of Neurology, Barts Health NHS Trust, The Royal London Hospital, London, UK.
Mult Scler. 2016 Nov;22(13):1759-1762. doi: 10.1177/1352458515627205. Epub 2016 Feb 8.
An altered balance of gonadal hormones in males with gender identity disorders (GIDs) may increase multiple sclerosis (MS) risk both inherently and secondary to treatment in undergoing male-to-female conversion.
We investigated any association between GIDs and MS through analysis of record-linked hospital statistics.
Analysis of English Hospital Episode Statistics, 1999-2012.
The adjusted rate ratio (RR) of MS following GIDs in males was 6.63 (95% confidence interval (95% CI) = 1.81-17.01, p = 0.0002). The RR of MS following GIDs in females was 1.44 (95% CI = 0.47-3.37, p = 0.58).
We report a strong association between GIDs and MS in male-to-females, supporting a potential role for low testosterone and/or feminising hormones on MS risk in males.
患有性别认同障碍（GID）的男性体内的性腺激素平衡发生改变，这可能会增加多发性硬化症（MS）的风险，这种风险既与疾病本身有关，也与接受男变女变性治疗有关。
我们通过分析与记录相关的医院统计数据来研究 GID 与 MS 之间的任何关联。
对 1999 年至 2012 年英国医院入院统计数据的分析。
在男性中，GID 后 MS 的调整后发病率比（RR）为 6.63（95%置信区间（95% CI）= 1.81-17.01，p=0.0002）。在女性中，GID 后 MS 的 RR 为 1.44（95% CI=0.47-3.37，p=0.58）。
我们报告了 GID 与男性向女性转变后的 MS 之间的强烈关联，这支持了低睾酮和/或女性化激素对男性 MS 风险的潜在作用。
