Frischknecht M, Flury C, Leeb T, Rieder S, Neuditschko M
Agroscope, Swiss National Stud Farm, Les Longs-Prés, 1580, Avenches, Switzerland.
Vetsuisse Faculty, Institute of Genetics, University of Bern, Bremgartenstrasse 109a, 3012, Bern, Switzerland.
Anim Genet. 2016 Jun;47(3):370-2. doi: 10.1111/age.12416. Epub 2016 Feb 9.
Shetland ponies were selected for numerous traits including small stature, strength, hardiness and longevity. Despite the different selection criteria, Shetland ponies are well known for their small stature. We performed a selection signature analysis including genome-wide SNPs of 75 Shetland ponies and 76 large-sized horses. Based upon this dataset, we identified a selection signature on equine chromosome (ECA) 1 between 103.8 Mb and 108.5 Mb. A total of 33 annotated genes are located within this interval including the IGF1R gene at 104.2 Mb and the ADAMTS17 gene at 105.4 Mb. These two genes are well known to have a major impact on body height in numerous species including humans. Homozygosity mapping in the Shetland ponies identified a region with increased homozygosity between 107.4 Mb and 108.5 Mb. None of the annotated genes in this region have so far been associated with height. Thus, we cannot exclude the possibility that the identified selection signature on ECA1 is associated with some trait other than height, for which Shetland ponies were selected.
设得兰矮种马因其众多特性被选育，这些特性包括矮小的身材、力量、耐寒性和长寿。尽管选择标准不同，但设得兰矮种马以其矮小的身材而闻名。我们进行了一项选择印记分析，包括75匹设得兰矮种马和76匹大型马的全基因组单核苷酸多态性（SNP）。基于该数据集，我们在马的1号染色体（ECA1）上103.8兆碱基（Mb）至108.5兆碱基之间鉴定出一个选择印记。该区间内共定位了33个注释基因，包括位于104.2兆碱基处的胰岛素样生长因子1受体（IGF1R）基因和位于105.4兆碱基处的含血小板反应蛋白基序的解聚蛋白样金属蛋白酶17（ADAMTS17）基因。众所周知，这两个基因对包括人类在内的众多物种的身高有重大影响。在设得兰矮种马中进行的纯合性定位确定了一个在107.4兆碱基至108.5兆碱基之间纯合性增加的区域。该区域目前没有注释基因与身高相关。因此，我们不能排除ECA1上鉴定出的选择印记与设得兰矮种马被选育的身高以外的某些性状相关的可能性。
