Caggiu Elisa, Paulus Kai, Arru Giannina, Piredda Rosanna, Sechi Gian Pietro, Sechi Leonardo A
Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Università di Sassari, Italy.
Dipartimento di Medicina Clinica e Sperimentale, Università di Sassari, Viale San Pietro 43b, 07100 Sassari, Italy.
J Neuroimmunol. 2016 Feb 15;291:110-4. doi: 10.1016/j.jneuroim.2016.01.007. Epub 2016 Jan 9.
Environmental factors are implicated in the development of Parkinson's disease (PD). We have investigated on the role of molecular mimicry between HSV1 and α-synuclein that could foster the progression of PD. The antibody response against homologous peptides in PD patients and healthy controls was evaluated, showing that these antibodies are highly prevalent among PD patients to healthy controls. The competitive assay demonstrated cross-reactivity between HSV1 and human α-synuclein peptides. The results may suggest the hypothesis of the involvement of HSV1 in stimulating the immune cells against the neurons of the substantia nigra as a consequence of the cross reactivity.
环境因素与帕金森病（PD）的发病有关。我们研究了单纯疱疹病毒1型（HSV1）与α-突触核蛋白之间分子模拟的作用，这种作用可能促进帕金森病的进展。评估了帕金森病患者和健康对照者对同源肽的抗体反应，结果显示这些抗体在帕金森病患者中比健康对照者更为普遍。竞争试验证明了HSV1与人α-突触核蛋白肽之间的交叉反应性。这些结果可能提示一个假说，即由于交叉反应性，HSV1参与刺激免疫细胞攻击黑质神经元。
