ElMaraachli Wael, Conrad Douglas J, Wang Angela C C
Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, 200 West Arbor Drive, MC 8372, San Diego, CA 92013, USA.
Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, 200 West Arbor Drive, MC 8372, San Diego, CA 92013, USA.
Clin Chest Med. 2016 Mar;37(1):139-46. doi: 10.1016/j.ccm.2015.11.005. Epub 2015 Dec 23.
Non-cystic fibrosis bronchiectasis (NCFB) is an increasingly prevalent disease that places a significant burden on patients and health systems globally. Although many of the therapies used to treat NCFB were originally developed as cystic fibrosis (CF) therapies, not all of them have been demonstrated to be efficacious in NCFB and some may even be harmful. This article explores the evidence for which therapeutic strategies used to treat CF have been translated into the care of NCFB. The conclusion is that therapies for adult NCFB cannot be simply extrapolated from CF clinical trials, and in some instances, doing so may actually result in harm.
非囊性纤维化支气管扩张症（NCFB）是一种日益普遍的疾病，给全球患者和卫生系统带来了沉重负担。尽管许多用于治疗NCFB的疗法最初是作为囊性纤维化（CF）疗法开发的，但并非所有这些疗法都已被证明在NCFB中有效，有些甚至可能有害。本文探讨了哪些用于治疗CF的治疗策略已被转化应用于NCFB的治疗。结论是，成人NCFB的治疗方法不能简单地从CF临床试验中推断出来，在某些情况下，这样做实际上可能会造成伤害。
