Faculty of Medicine, Clinical and Experimental Sciences, University of Southampton, Southampton General Hospital, Southampton, UK.
Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK.
COPD. 2021 Jun;18(3):341-348. doi: 10.1080/15412555.2021.1920904. Epub 2021 May 6.
Pertussis is underdiagnosed and underreported in adults and patients with underlying conditions. Patients with chronic obstructive pulmonary disease (COPD) may be at increased risk of severe pertussis. Understanding the true prevalence of pertussis infections in such patients is important. We therefore evaluated the seroprevalence of anti-pertussis toxin (PT) antibodies in a cohort of 40-85-year-old patients diagnosed with moderate, severe or very severe COPD enrolled (between June 2011 and June 2012) in the prospective, observational "Acute Exacerbation and Respiratory InfectionS in COPD" (AERIS; NCT01360398) study, conducted in England. Serum anti-PT antibodies were measured in 104 patients using an enzyme-linked immunosorbent assay on samples collected 12 months (M12) and 24 months (M24) after enrollment. Overall, 14/104 (13.5%) patients had anti-PT concentrations ≥50 IU/mL at M12 or M24, indicative of exposure to during the preceding 2-3 years. Of these, 6/104 (5.8%) had anti-PT ≥70 IU/mL, of whom 3/104 (2.9%) had anti-PT ≥120 IU/mL, indicative of exposure within 12 and 6 months, respectively. These results show a high circulation of in 40-85-year-old patients with moderate, severe or very severe COPD in England between 2012 and 2014, and call for enhanced immunization to prevent pertussis infections in such patients.
百日咳在成年人和有基础疾病的患者中诊断不足且报告不足。患有慢性阻塞性肺疾病（COPD）的患者可能有患严重百日咳的风险增加。了解此类患者中百日咳感染的真实流行情况很重要。因此，我们评估了在 2011 年 6 月至 2012 年 6 月期间入组的前瞻性、观察性“COPD 急性加重和呼吸道感染”（AERIS；NCT01360398）研究中诊断为中度、重度或极重度 COPD 的 40-85 岁患者队列中的抗百日咳毒素（PT）抗体的血清阳性率，该研究在英国进行。在入组后 12 个月（M12）和 24 个月（M24），使用酶联免疫吸附试验（ELISA）在 104 例患者的样本中测量血清抗-PT 抗体。总的来说，在 M12 或 M24 时，有 14/104（13.5%）例患者的抗-PT 浓度≥50IU/mL，表明在过去 2-3 年内曾接触过 。其中，6/104（5.8%）例患者的抗-PT≥70IU/mL，其中 3/104（2.9%）例患者的抗-PT≥120IU/mL，分别表示在 12 个月和 6 个月内接触过。这些结果表明，在 2012 年至 2014 年间，英国 40-85 岁患有中度、重度或极重度 COPD 的患者中，存在大量的 循环，需要加强免疫接种以预防此类患者的百日咳感染。
