Chandler Paulette D, Agboola Foluso, Ng Kimmie, Scott Jamil B, Drake Bettina F, Bennett Gary G, Chan Andrew T, Hollis Bruce W, Emmons Karen M, Fuchs Charles S, Giovannucci Edward L
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA.
Division of Policy Translation and Leadership Development, Harvard School of Public Health, Boston, MA.
BMC Nutr. 2015;1. doi: 10.1186/s40795-015-0024-8. Epub 2015 Dec 17.
Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Conflicting reports in Blacks exist on the PTH response to vitamin D to supplementation.
During 3 winters from 2007-2010, 328 healthy Blacks (median age, 51 years) living in Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. PTH was measured in 254 participants at baseline and at the end of vitamin D supplementation period.
The differences in PTH between baseline and 3 months were 3.93 pg/mL for those receiving placebo, -3.37 pg/mL for those receiving 1000 IU/d, -6.76 pg/mL for those receiving 2000 IU/d, and -8.99 pg/mL for those receiving 4000 IU/d ( -2.98 pg/mL for each additional 1000 IU/d of vitamin D3; p<0.001).
We found a significant decrease in PTH with increasing doses of vitamin D supplementation up to intakes of 4000 IU/d in Blacks. Clinical Trials.gov: NCT00585637.
甲状旁腺激素（PTH）对维生素D补充剂的反应取决于基线PTH水平和维生素D状态的变化。关于黑人中PTH对维生素D补充剂的反应，存在相互矛盾的报道。
在2007年至2010年的3个冬季期间，将328名居住在马萨诸塞州波士顿的健康黑人（中位年龄51岁）随机分为四组，进行为期3个月的双盲试验，分别给予安慰剂、1000、2000或4000国际单位的维生素D3。在254名参与者的基线和维生素D补充期结束时测量PTH。
接受安慰剂的参与者基线与3个月时PTH的差异为3.93 pg/mL，接受1000 IU/d的参与者为-3.37 pg/mL，接受2000 IU/d的参与者为-6.76 pg/mL，接受4000 IU/d的参与者为-8.99 pg/mL（每增加1000 IU/d的维生素D3，差异为-2.98 pg/mL；p<0.001）。
我们发现，在黑人中，随着维生素D补充剂剂量增加至每日4000 IU，PTH显著降低。临床试验.gov：NCT00585637。
