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The possible perils of targeted therapy.

作者信息

Duffner U, Abdel-Mageed A, Younge J, Tornga C, Scott K, Staddon J, Elliott K, Stumph J, Kidd P

机构信息

Division of Pediatric Blood & Bone marrow Transplantation at Helen DeVos Children's Hospital, Grand Rapids, MI, USA.

Spectrum Health and Michigan State University, Department of Pediatrics & Human Development, Grand Rapids, MI, USA.

出版信息

Leukemia. 2016 Jul;30(7):1619-21. doi: 10.1038/leu.2016.18. Epub 2016 Feb 9.

DOI:10.1038/leu.2016.18
PMID:26859079
Abstract
摘要

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Enhancing adoptive CD8 T cell therapy by systemic delivery of tumor associated antigens.通过全身递送肿瘤相关抗原增强过继性 CD8 T 细胞治疗。

本文引用的文献

1
Clinical overview of anti-CD19 BiTE(®) and ex vivo data from anti-CD33 BiTE(®) as examples for retargeting T cells in hematologic malignancies.抗CD19双特异性T细胞衔接器（BiTE）的临床概述以及抗CD33双特异性T细胞衔接器（BiTE）的体外数据，作为血液系统恶性肿瘤中T细胞重定向的实例
Mol Immunol. 2015 Oct;67(2 Pt A):58-66. doi: 10.1016/j.molimm.2015.02.033. Epub 2015 Apr 13.
2
MLL leukemia and future treatment strategies.MLL 白血病与未来的治疗策略。
Arch Pharm (Weinheim). 2015 Apr;348(4):221-8. doi: 10.1002/ardp.201400449. Epub 2015 Mar 4.
3
Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia.
Sci Rep. 2021 Oct 5;11(1):19794. doi: 10.1038/s41598-021-99347-0.
4
Blinatumomab for HLA loss relapse after haploidentical hematopoietic stem cell transplantation.单倍体造血干细胞移植后HLA缺失复发的博纳吐单抗治疗
Am J Cancer Res. 2021 Jun 15;11(6):3111-3122. eCollection 2021.
5
[CD19 antigen loss after treatment of Bispecific T-cell Engager and effective response to salvage bispecific CAR-T therapy in B cell acute lymphoblastic leukemia: a case report and literature review].[双特异性T细胞衔接器治疗后CD19抗原丢失及对挽救性双特异性嵌合抗原受体T细胞疗法在B细胞急性淋巴细胞白血病中的有效反应：一例报告及文献综述]
Zhonghua Xue Ye Xue Za Zhi. 2020 Apr 14;41(4):282-286. doi: 10.3760/cma.j.issn.0253-2727.2020.04.004.
6
Immunotherapy- (Blinatumomab-) Related Lineage Switch of Rearranged B-Lymphoblastic Leukemia into Acute Myeloid Leukemia/Myeloid Sarcoma and Subsequently into B/Myeloid Mixed Phenotype Acute Leukemia.免疫疗法（博纳吐单抗相关）导致重排的B淋巴细胞白血病转变为急性髓系白血病/髓系肉瘤，随后又转变为B/髓系混合表型急性白血病。
Case Rep Hematol. 2019 Dec 7;2019:7394619. doi: 10.1155/2019/7394619. eCollection 2019.
7
Blinatumomab-induced lineage switch of B-ALL with t(4:11)(q21;q23) KMT2A/AFF1 into an aggressive AML: pre- and post-switch phenotypic, cytogenetic and molecular analysis.blinatumomab诱导的伴有t(4:11)(q21;q23) KMT2A/AFF1的B淋巴细胞白血病向侵袭性急性髓系白血病的谱系转换：转换前后的表型、细胞遗传学和分子分析
Blood Cancer J. 2017 Sep 15;7(9):e607. doi: 10.1038/bcj.2017.89.
8
Antigen Loss Variants: Catching Hold of Escaping Foes.抗原丢失变体：抓住逃脱的敌人
Front Immunol. 2017 Feb 24;8:175. doi: 10.3389/fimmu.2017.00175. eCollection 2017.
抗 CD19 双特异性 T 细胞衔接蛋白blinatumomab 的 II 期临床试验显示，复发或难治性 B 前体急性淋巴细胞白血病患者有血液学和分子缓解。
J Clin Oncol. 2014 Dec 20;32(36):4134-40. doi: 10.1200/JCO.2014.56.3247. Epub 2014 Nov 10.
4
CD2-positive B-cell precursor acute lymphoblastic leukemia with an early switch to the monocytic lineage.CD2 阳性 B 细胞前体急性淋巴细胞白血病向单核细胞系早期分化。
Leukemia. 2014 Mar;28(3):609-20. doi: 10.1038/leu.2013.354. Epub 2013 Nov 25.
5
Lineage switch in childhood acute leukemia: an unusual event with poor outcome.儿童急性白血病中的谱系转换：一种不良预后的不常见事件。
Am J Hematol. 2012 Sep;87(9):890-7. doi: 10.1002/ajh.23266. Epub 2012 Jun 8.
6
Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival.针对化疗耐药的 B 系急性淋巴细胞白血病患者微小残留病灶的 T 细胞结合抗体blinatumomab 的靶向治疗可带来高缓解率和延长无白血病生存。
J Clin Oncol. 2011 Jun 20;29(18):2493-8. doi: 10.1200/JCO.2010.32.7270. Epub 2011 May 16.
7
Acute monocytic leukaemia originating from MLL-MLLT3-positive pre-B cells.
Br J Haematol. 2010 Sep;150(5):621-3. doi: 10.1111/j.1365-2141.2010.08239.x. Epub 2010 May 20.
8
Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?正常造血与白血病造血：白血病是干细胞疾病还是干细胞特性的重新获得？
Proc Natl Acad Sci U S A. 2003 Sep 30;100 Suppl 1(Suppl 1):11842-9. doi: 10.1073/pnas.2034201100. Epub 2003 Sep 22.
9
Bipotential B-macrophage progenitors are present in adult bone marrow.双潜能B巨噬细胞祖细胞存在于成年骨髓中。
Nat Immunol. 2001 Jan;2(1):83-8. doi: 10.1038/83210.