Hofstad T
Department of Microbiology and Immunology, Gade Institute, University of Bergen, Norway.
Scand J Infect Dis Suppl. 1989;62:15-24.
The literature dealing with adherence, host-protective mechanisms and tissues damaging products of nonsporeforming anaerobes is reviewed. The adherence mechanisms are poorly understood. There is evidence for that encapsulation plays a role in the pathogenicity of Bacteroides fragilis and black-pigmented bacteroides. A leukocidin is produced by Fusobacterium necrophorum, and Ig protease, collagenase and a trypsin-like enzyme by some Bacteroides species. Some Bacteroides fragilis strains produce an enterotoxin. The pathogenetic role of endotoxin is unclear.
本文综述了有关非芽孢厌氧菌的黏附、宿主保护机制及组织损伤产物的文献。黏附机制目前了解甚少。有证据表明，荚膜在脆弱拟杆菌和产黑色素拟杆菌的致病性中起作用。坏死梭杆菌可产生一种白细胞毒素，某些拟杆菌属菌种可产生免疫球蛋白蛋白酶、胶原酶和一种类胰蛋白酶。一些脆弱拟杆菌菌株可产生一种肠毒素。内毒素的致病作用尚不清楚。
