Hofstad T
Department of Microbiology and Immunology, Gade Institute, Bergen, Norway.
Eur J Clin Microbiol Infect Dis. 1992 Nov;11(11):1044-8. doi: 10.1007/BF01967797.
Various surface structures can be expressed in Bacteroides fragilis, but little is known about capsular structures in other non-spore-forming anaerobes. Fimbriae have been isolated from Bacteroides fragilis and Porphyromonas gingivalis. The importance of iron-repressible outer membrane proteins as virulence factors in Bacteroides fragilis is under study. The low endotoxic activity of Bacteroides fragilis lipopolysaccharide can be attributed to the chemical composition of this organism's lipid A. A tissue culture system for the demonstration of Bacteroides fragilis enterotoxin has recently been described. The toxins A and B of Clostridium difficile are immunologically distinct. The importance of IgA proteases and other enzymes as virulence factors in anaerobic bacteria remains unclear.
脆弱拟杆菌可表达多种表面结构，但对于其他非产芽孢厌氧菌的荚膜结构了解甚少。已从脆弱拟杆菌和牙龈卟啉单胞菌中分离出菌毛。脆弱拟杆菌中铁可抑制外膜蛋白作为毒力因子的重要性正在研究中。脆弱拟杆菌脂多糖的低内毒素活性可归因于该菌脂质A的化学组成。最近描述了一种用于展示脆弱拟杆菌肠毒素的组织培养系统。艰难梭菌的毒素A和毒素B在免疫学上是不同的。IgA蛋白酶和其他酶作为厌氧菌毒力因子的重要性仍不清楚。
