Misset J L, Venuat A M, Nevarez L, Mathé G
Nouv Presse Med. 1977;6(27):2409-13.
In ten cases of apparently primary acute leukaemia, the discovery of a Philadelphia chromosome at routine examination of the caryotype led a diagnosis of blastic crisis of chronic myeloid leukemia. The clinical, cytological and cytogenetic pictures varied and only routine caryotypic examination may be used in reaching the diagnosis. The prognosis appear to be less bad than in blastic crises occurring after a long course of chronic myeloid leukaemia and closer to that of primary acute myeloid leukaemia.
在10例看似原发性急性白血病的病例中，常规核型检查发现费城染色体，从而诊断为慢性粒细胞白血病的原始细胞危象。临床、细胞学和细胞遗传学表现各不相同，只有常规核型检查可用于做出诊断。其预后似乎不像慢性粒细胞白血病病程较长后发生的原始细胞危象那样差，更接近原发性急性髓细胞白血病的预后。
