Mintz U, Bar-Meir S, Pinkhas J, De Vries A
Haematologia (Budap). 1975;9(3-4):257-60.
A patient is described in whom CML first presented as blastic crisis. The diagnosis of CML was based upon the findings of Ph(1) chromosome in the bone marrow, basophilia in the peripheral blood, absence of NAP activity in the leukocytes, elevated serum vitamin B(12) and an enlarged firm spleen. CML with blastic crisis as its first expression is relatively rare, as compared to CML in which blastic crisis appears as a phase of prolonged clinically manifest disease.
本文描述了一位以原始细胞危象首次表现的慢性粒细胞白血病患者。慢性粒细胞白血病的诊断基于骨髓中Ph(1)染色体的发现、外周血嗜碱性粒细胞增多、白细胞中无NAP活性、血清维生素B12升高以及脾脏肿大坚实。与慢性粒细胞白血病原始细胞危象表现为临床病程较长阶段的情况相比，以原始细胞危象为首发表现的慢性粒细胞白血病相对少见。
