Kuhfahl E
Abteilung Klinische Laboratorien, Bezirkskrankenhauses Dresden-Neustadt.
Z Gesamte Inn Med. 1989 Oct 1;44(19):574-7.
The skeletal muscle and the myocardium (musculature) are involved in the turnover rate of free fatty acids (FFA) with a third. Disturbances of the FFA metabolism of the musculature result in a restriction of the function which appears as a diminished contractility and, as far as the myocardium is concerned, additionally as arrhythmias. Moreover the restriction of the FFA utilization by the muscles plays a role in the origin of hyperlipacidaemias participating in the pathogenesis of various acute and chronic extramuscular functional disturbances (e.g. thrombophilia, disorders of the capillary circulation, hyperlipoproteinaemia, postnatal hypoglycaemia). With regard to its clinical relevance a survey is given of the FFA muscular metabolism. The author deals with the factors affecting the FFA netto bilance of the muscles and in this connection the regulation of the lipolysis, the triglyceride synthesis and the fatty acid oxidation. Finally the relation between the FFA and glucose metabolism in the muscles is described.
骨骼肌和心肌（肌肉组织）参与了游离脂肪酸（FFA）三分之一的周转率。肌肉组织中FFA代谢紊乱会导致功能受限，表现为收缩力减弱，就心肌而言，还会出现心律失常。此外，肌肉对FFA利用的受限在高脂血症的发生中起作用，参与各种急性和慢性肌肉外功能障碍（如血栓形成倾向、毛细血管循环障碍、高脂蛋白血症、产后低血糖）的发病机制。关于其临床相关性，对FFA肌肉代谢进行了综述。作者探讨了影响肌肉FFA净平衡的因素，并在此方面涉及脂肪分解、甘油三酯合成和脂肪酸氧化的调节。最后描述了肌肉中FFA与葡萄糖代谢之间的关系。
