Kuhfahl E
Abteilung Klinische Laboratorien, Bezirkskrankenhauses Dresden-Neustadt.
Z Gesamte Inn Med. 1989 Apr 15;44(8):225-8.
The liver participates in the turnover rate of free fatty acids (FFA) with a third. A severe disruption of liver function that occurs in cirrhosis leads therefore to a pathogenetic relevant hyperlipacidaemia respectively increases that. With regard to its clinical relevance a survey is given of the FFA metabolism of the liver. The factors are described which influence the FFA uptake by this organ. In this connection the metabolic fate of the FFA in dependence on the hormonal nutritive state is depicted. The author deals with the relation of the hepatic FFA metabolism to that of triglycerides, cholesterol, ketone bodies, carbohydrates, amino acids and insulin. The importance of these relatons for the caloric homeostasis and for the pathogenesis of various acute and chronic functional disturbances (ketoacidosis, negative nitrogen-balance, hyperlipoproteinaemia, hyperinsulinism, atherosclerosis) is described.
肝脏参与了三分之一的游离脂肪酸（FFA）周转率。肝硬化时发生的严重肝功能损害会导致与发病机制相关的高脂血症，进而加重这种情况。关于其临床相关性，本文对肝脏的FFA代谢进行了综述。描述了影响该器官摄取FFA的因素。在此方面，还描述了FFA在依赖激素营养状态下的代谢归宿。作者探讨了肝脏FFA代谢与甘油三酯、胆固醇、酮体、碳水化合物、氨基酸和胰岛素代谢之间的关系。阐述了这些关系对热量稳态以及各种急慢性功能障碍（酮症酸中毒、负氮平衡、高脂蛋白血症、高胰岛素血症、动脉粥样硬化）发病机制的重要性。
