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从牛心中分离和鉴定脂肪族短链酰基肉碱：肉碱在支链氨基酸代谢中的可能作用。

Isolation and identification of aliphatic short-chain acylcarnitines from beef heart: possible role for carnitine in branched-chain amino acid metabolism.

作者信息

Bieber L L, Choi Y R

出版信息

Proc Natl Acad Sci U S A. 1977 Jul;74(7):2795-8. doi: 10.1073/pnas.74.7.2795.

DOI:10.1073/pnas.74.7.2795
PMID:268629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC431294/
Abstract

Aliphatic acylearnitines isolated from a water-soluble fraction of beef heart have been characterized by gas chromatography and mass spectrometry. The following acyl residues derived from the acylcarnitine fraction were unequivocally identified: acetyl, propionyl, isobutyryl, butyryl, alpha-methylbutyryl, valeryl, isovaleryl, tiglyl, and caproyl. beta-methylcrotonyl and methacrylyl were tentatively identified. This occurrence of considerable quantities of branched-chain acylcarnitines indicates a role for carnitine in branched-chain amino acid metabolism.

摘要

从牛心水溶性部分分离出的脂肪酰肉碱已通过气相色谱法和质谱法进行了表征。从酰基肉碱部分衍生出的以下酰基残基已被明确鉴定：乙酰基、丙酰基、异丁酰基、丁酰基、α-甲基丁酰基、戊酰基、异戊酰基、惕各酰基和己酰基。β-甲基巴豆酰基和甲基丙烯酰基被初步鉴定。大量支链酰基肉碱的存在表明肉碱在支链氨基酸代谢中起作用。

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Isolation and identification of aliphatic short-chain acylcarnitines from beef heart: possible role for carnitine in branched-chain amino acid metabolism.从牛心中分离和鉴定脂肪族短链酰基肉碱：肉碱在支链氨基酸代谢中的可能作用。
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本文引用的文献

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Branched chain alpha-keto acid metabolism. II. Evidence for the common identity of alpha-ketoisocaproic acid and alpha-keto-beta-methyl-valeric acid dehydrogenases.支链α-酮酸代谢。II. α-酮异己酸和α-酮-β-甲基戊酸脱氢酶共同同一性的证据。
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