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Regeneration: Stem cells make the bowel nervous.

作者信息

Heuckeroth Robert O

机构信息

Children's Hospital of Philadelphia Research Institute and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

出版信息

Nature. 2016 Mar 3;531(7592):44-5. doi: 10.1038/nature16877. Epub 2016 Feb 10.

DOI:10.1038/nature16877
PMID:26863191
Abstract
摘要

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Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease.为先天性巨结肠症的细胞治疗和药物研发获取人类肠神经系统谱系。
Nature. 2016 Mar 3;531(7592):105-9. doi: 10.1038/nature16951. Epub 2016 Feb 10.
2
A developmental framework for induced pluripotency.诱导多能性的发育框架。
Development. 2015 Oct 1;142(19):3274-85. doi: 10.1242/dev.114249.
3
Building a second brain in the bowel.在肠道中构建第二个大脑。
神经连接蛋白1和神经细胞黏附分子1对神经元性肠发育异常小鼠模型结肠运动的影响
Gastroenterol Res Pract. 2020 Jan 4;2020:9818652. doi: 10.1155/2020/9818652. eCollection 2020.
4
"Too much guts and not enough brains": (epi)genetic mechanisms and future therapies of Hirschsprung disease - a review.“太多的勇气，而不是足够的头脑”：（表观遗传学）遗传机制与先天性巨结肠病的未来治疗方法——综述。
Clin Epigenetics. 2019 Sep 13;11(1):135. doi: 10.1186/s13148-019-0718-x.
5
DRG-Derived Neural Progenitors Differentiate into Functional Enteric Neurons Following Transplantation in the Postnatal Colon.DRG 源性神经前体细胞在出生后结肠移植后可分化为功能性肠神经元。
Cell Transplant. 2019 Feb;28(2):157-169. doi: 10.1177/0963689718811061. Epub 2018 Nov 15.
6
White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies.关于肠道神经系统干细胞治疗肠道神经病变的指南白皮书
Dev Biol. 2016 Sep 15;417(2):229-51. doi: 10.1016/j.ydbio.2016.04.001. Epub 2016 Apr 5.
J Clin Invest. 2015 Mar 2;125(3):899-907. doi: 10.1172/JCI76307. Epub 2015 Feb 9.
4
Nutrient-induced changes in the phenotype and function of the enteric nervous system.营养物质诱导的肠神经系统表型和功能变化。
J Physiol. 2014 Jul 15;592(14):2959-65. doi: 10.1113/jphysiol.2014.272948. Epub 2014 Jun 6.
5
Neural stem cell therapies for enteric nervous system disorders.用于治疗肠神经系统紊乱的神经干细胞疗法。
Nat Rev Gastroenterol Hepatol. 2014 May;11(5):317-28. doi: 10.1038/nrgastro.2013.226. Epub 2013 Dec 10.
6
Advances in Hirschsprung disease genetics and treatment strategies: an update for the primary care pediatrician.先天性巨结肠症遗传学与治疗策略的进展：给基层儿科医生的最新资讯
Clin Pediatr (Phila). 2014 Jan;53(1):71-81. doi: 10.1177/0009922813500846. Epub 2013 Sep 3.
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Hirschsprung disease: a developmental disorder of the enteric nervous system.先天性巨结肠症：一种肠道神经系统的发育障碍疾病。
Wiley Interdiscip Rev Dev Biol. 2013 Jan-Feb;2(1):113-29. doi: 10.1002/wdev.57. Epub 2012 Apr 24.
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The enteric nervous system and neurogastroenterology.肠神经系统与神经胃肠病学。
Nat Rev Gastroenterol Hepatol. 2012 Mar 6;9(5):286-94. doi: 10.1038/nrgastro.2012.32.
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Annu Rev Physiol. 1999;61:117-42. doi: 10.1146/annurev.physiol.61.1.117.