1-芳基环丙烷-2-烯-1-甲酰胺的高效一锅法合成
Efficient one-pot synthesis of 1-arylcycloprop-2-ene-1-carboxamides.
作者信息
Edwards Andrew, Rubin Michael
机构信息
Department of Chemistry, University of Kansas, 1251 Wescoe Hall Dr., Lawrence, KS 66045-7582, USA.
出版信息
Org Biomol Chem. 2016 Mar 14;14(10):2883-90. doi: 10.1039/c6ob00156d.
Abstract
An expeditious and cost-efficient method for synthesis of 1-arylcycloprop-2-ene-1-carboxamides was developed. This one-pot protocol involving coupling of amines with acyl chlorides, generated upon treatment of cyclopenylcarboxylic acids with oxalyl chloride, is applicable for the preparation of sensitive products with a reactive, unsubstituted strained double bond.
摘要
开发了一种快速且经济高效的合成1-芳基环丙-2-烯-1-甲酰胺的方法。该一锅法方案涉及胺与酰氯的偶联，酰氯是在用草酰氯处理环戊基羧酸时生成的，适用于制备具有反应性、未取代的张力双键的敏感产物。
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