Hanabusa Masao, Yoshihara Kumiko, Yoshida Yasuhiro, Okihara Takumi, Yamamoto Takatsugu, Momoi Yasuko, Van Meerbeek Bart
Department of Operative Dentistry, Tsurumi University School of Dental Medicine, Yokohama, Japan.
Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan.
Eur J Oral Sci. 2016 Apr;124(2):204-9. doi: 10.1111/eos.12245. Epub 2016 Feb 11.
The degree of conversion (DC) of camphorquinone/amine-based adhesives is affected by acidic functional monomers as a result of inactivation of the amine co-initiator through an acid-base reaction. During bonding, functional monomers of self-etch adhesives chemically interact with hydroxyapatite (HAp). Here, we tested in how far the latter interaction of functional monomers with HAp counteracts the expected reduction in DC of camphorquinone/amine-based adhesives. The DC of three experimental adhesive formulations, containing either of the two functional monomers [10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) or 4-methacryloxyethyl trimellitic acid anhydride (4-META)] or no functional monomer (no-FM; control), was measured with and without HAp powder added to the adhesive formulations. Both the variables 'functional monomer' and 'HAp' were found to be significant, with the functional monomer reducing the DC and HAp counteracting this effect. It is concluded that the functional monomers 10-MDP and 4-META interfere with the polymerization efficiency of adhesives. This interference is less prominent in the presence of HAp, which would clinically correspond to when these two functional monomers of the adhesive simultaneously interact with HAp in tooth tissue.
由于胺类共引发剂通过酸碱反应失活，樟脑醌/胺基粘合剂的转化率（DC）受酸性功能单体的影响。在粘结过程中，自酸蚀粘合剂的功能单体与羟基磷灰石（HAp）发生化学相互作用。在此，我们测试了功能单体与HAp的后一种相互作用在多大程度上抵消了樟脑醌/胺基粘合剂预期的DC降低。在添加和不添加HAp粉末到粘合剂配方的情况下，测量了三种实验性粘合剂配方的DC，这三种配方分别含有两种功能单体中的一种[10-甲基丙烯酰氧基癸基磷酸二氢酯（10-MDP）或4-甲基丙烯酰氧基乙基偏苯三酸酐（4-META）]或不含功能单体（无功能单体；对照）。发现“功能单体”和“HAp”这两个变量都具有显著性，功能单体降低DC，而HAp抵消这种效应。得出的结论是，功能单体10-MDP和4-META会干扰粘合剂的聚合效率。在存在HAp的情况下，这种干扰不太明显，这在临床上相当于粘合剂的这两种功能单体同时与牙齿组织中的HAp相互作用时的情况。
