Vylegzhanina E S, Dmitrieva N F, Naumova I B, Chekanova Iu I, Epishin Iu N, Oksman T M
Antibiot Khimioter. 1989 Aug;34(8):572-9.
Lipoteichoic acid (LTA) of group A streptococci, type M 29 was studied. Chemical and 13C NMR spectroscopic analysis showed that the polymer contained poly(glycerophosphate) chain consisting of 12-14 glycerophosphate elements united by the 1----3 type phosphodiether bond and diglucosylglyceride. Oleic, stearic, palmitic and palmitoleic fatty acids predominated in the polymer composition. The content of the fatty acids amounted approximately to 2 per cent of LTA dry weight. The poly(glycerophosphate) chain contained 6-7 ether linked alanyl moieties. The results of the LTA biological study were analyzed in comparison to the data on a previous study of antitumor and cardiotoxic properties of teichoic acid from Streptomyces levoris K-3053 which is structurally close to the LTA hydrophilic moiety. It was assumed that the molecule negative charge had an effect on the cardiotoxic and antitumor activity.
对A组M29型链球菌的脂磷壁酸（LTA）进行了研究。化学和13C核磁共振光谱分析表明，该聚合物含有由12 - 14个甘油磷酸单元通过1→3型磷酸二醚键连接而成并带有二葡糖基甘油酯的聚（甘油磷酸）链。聚合物组成中以油酸、硬脂酸、棕榈酸和棕榈油酸为主。脂肪酸含量约占LTA干重的2%。聚（甘油磷酸）链含有6 - 7个醚键连接的丙氨酰部分。将LTA生物学研究结果与之前对来自左旋链霉菌K - 3053的磷壁酸的抗肿瘤和心脏毒性特性研究数据进行了比较分析，该磷壁酸在结构上与LTA亲水部分相近。据推测，分子负电荷对心脏毒性和抗肿瘤活性有影响。
