Choi Seung Kwon, Chang Ji Woong
Department of Ophthalmology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
Korean J Ophthalmol. 2016 Feb;30(1):53-9. doi: 10.3341/kjo.2016.30.1.53. Epub 2016 Jan 21.
To investigate the changes in corneal higher-order aberration (HOA) during amblyopia treatment and the correlation between HOA and astigmatism in hyperopic amblyopia children.
In this retrospective study, a total of 72 eyes from 72 patients ranging in age from 38 to 161 months were included. Patients were divided into two groups based on the degree of astigmatism. Corneal HOA was measured using a KR-1W aberrometer at the initial visit and at 3-, 6-, and 12-month follow-ups. Correlation analysis was performed to assess the association between HOA and astigmatism.
A total of 72 patients were enrolled in this study, 37 of which were classified as belonging to the higher astigmatism group, while 35 were assigned to the lower astigmatism group. There was a statistically significant difference in success rate between the higher and lower astigmatism groups. In both groups, all corneal HOAs were significantly reduced during amblyopia treatment. When comparing the two groups, a significant difference in coma HOA at the 12-month follow-up was detected (p = 0.043). In the Pearson correlation test, coma HOA at the 12-month follow-up demonstrated a statistically significant correlation with astigmatism and a stronger correlation with astigmatism in the higher astigmatism group than in the lower astigmatism group (coefficient values, 0.383 and 0.284 as well as p = 0.021 and p = 0.038, respectively).
HOA, particularly coma HOA, correlated with astigmatism and could exert effects in cases involving hyperopic amblyopia.
探讨弱视治疗期间角膜高阶像差（HOA）的变化以及远视性弱视儿童中HOA与散光之间的相关性。
在这项回顾性研究中，纳入了72例年龄在38至161个月之间的患者的72只眼。根据散光程度将患者分为两组。在初次就诊时以及3个月、6个月和12个月随访时，使用KR-1W像差仪测量角膜HOA。进行相关性分析以评估HOA与散光之间的关联。
本研究共纳入72例患者，其中37例被归类为高散光组，35例被分配到低散光组。高散光组和低散光组之间的成功率存在统计学显著差异。在两组中，弱视治疗期间所有角膜HOA均显著降低。比较两组时，在12个月随访时发现彗差HOA存在显著差异（p = 0.043）。在Pearson相关性检验中，12个月随访时的彗差HOA与散光存在统计学显著相关性，并且在高散光组中与散光的相关性比低散光组更强（系数值分别为0.383和0.284，p值分别为0.021和0.038）。
HOA，尤其是彗差HOA，与散光相关，并且在涉及远视性弱视的病例中可能发挥作用。
