Lecomte F, Mihout B, Humbert G
Department of Infectious Diseases, Hôpital Charles Nicolle, Rouen, France.
Biomed Pharmacother. 1989;43(6):409-13. doi: 10.1016/0753-3322(89)90238-2.
Lyme disease is a multi-systemic infection due to B. burgdorferi, with neurological manifestations observed in its second and third stages. Except for the suggestive triad meningitis--radiculoneuritis--facial palsies, the diagnosis is often difficult because of the pleiomorphism of neurological manifestations. These can be localized or diffuse, with central involvement, meningitis or peripheral manifestations. Past history, cerebrospinal fluid (CSF) examination, immuno-assays for specific antibodies in serum and especially CSF are helpful in diagnosis. Betalactam antibiotics (penicillin G, amoxicillin, and third generation cephalosporins) are the most effective treatment with good results in the early and acute stages of neurological disease.
莱姆病是由伯氏疏螺旋体引起的多系统感染，在其二期和三期会出现神经学表现。除了具有提示性的三联征——脑膜炎、神经根神经炎、面瘫外，由于神经学表现的多形性，诊断往往很困难。这些表现可为局限性或弥漫性，可累及中枢、出现脑膜炎或周围性表现。既往病史、脑脊液（CSF）检查、血清尤其是脑脊液中特异性抗体的免疫测定有助于诊断。β-内酰胺类抗生素（青霉素G、阿莫西林和第三代头孢菌素）是最有效的治疗药物，在神经疾病的早期和急性期效果良好。
