1型糖尿病患者甲状腺功能障碍的发病率和患病率。
Incidence and prevalence of thyroid dysfunction in type 1 diabetes.
作者信息
Nederstigt Christa, Corssmit Eleonora P M, de Koning Eelco J P, Dekkers Olaf M
机构信息
Department of Internal Medicine, Section Endocrinology, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands; Department of Clinical Epidemiology, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands; Medisch Centrum Haaglanden, Department of Internal Medicine, Lijnbaan 32, 2512 VA Den Haag, The Netherlands.
Department of Internal Medicine, Section Endocrinology, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands.
出版信息
J Diabetes Complications. 2016 Apr;30(3):420-5. doi: 10.1016/j.jdiacomp.2015.12.027. Epub 2016 Jan 6.
AIMS
To estimate prevalence and incidence of auto-immune thyroid disease and thyroid auto-antibodies in an unselected cohort of patients with DM1, including stratification by age, gender and duration of diabetes.
METHODS
Patients with T1D visiting our outpatient clinic between 1995 and 2011 were included. We calculated the prevalence of AITD at first screening and estimated prevalence and incidence rates during follow-up.
RESULTS
A total of 1304 patients were included, 48.9% being female. Mean age of diabetes onset was 18.7 years. Of all patients without known thyroid disorder first screened for AITD, 10.3 % (n=104) was diagnosed with hypo- or hyperthyroidism. The average prevalence of AITD in our population was 112/1000 patients. We found 128 new cases of AITD, 101 cases of hypothyroidism and 27 of hyperthyroidism between 1995 and 2011 with accompanying incidences of 11.2/1000 person-years (95% CI 9.5-13.4), 8.9/1000 person-years (95% CI, 7.3-10.8) and 2.4/1000 person-years (95% CI, 1.6-3.5), respectively. Age-stratified incidence of AITD was comparable at all ages in both males and females, with an approximately two times higher incidence in females.
CONCLUSIONS
The incidence of AITD among T1D patients is high, but stable among all ages and independent of diabetes duration.
目的
评估1型糖尿病（DM1）非选择性队列中自身免疫性甲状腺疾病及甲状腺自身抗体的患病率和发病率，包括按年龄、性别和糖尿病病程进行分层。
方法
纳入1995年至2011年间在我们门诊就诊的1型糖尿病患者。我们计算了首次筛查时自身免疫性甲状腺疾病（AITD）的患病率，并估计了随访期间的患病率和发病率。
结果
共纳入1304例患者，其中48.9%为女性。糖尿病发病的平均年龄为18.7岁。在所有首次筛查AITD且无已知甲状腺疾病的患者中，10.3%（n = 104）被诊断为甲状腺功能减退或亢进。我们人群中AITD的平均患病率为112/1000例患者。1995年至2011年间，我们发现128例新的AITD病例，其中101例为甲状腺功能减退，27例为甲状腺功能亢进，相应的发病率分别为11.2/1000人年（95%可信区间9.5 - 13.4）、8.9/1000人年（95%可信区间7.3 - 10.8）和2.4/1000人年（95%可信区间1.6 - 3.5）。AITD的年龄分层发病率在男性和女性的所有年龄段中相当，女性发病率约高两倍。
结论
1型糖尿病患者中AITD的发病率较高，但在所有年龄段中稳定，且与糖尿病病程无关。
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