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沙特阿拉伯一家诊所数据中糖尿病、肥胖症和甲状腺功能障碍之间关联的推断。

Inference of link among diabetes, obesity, and thyroid dysfunction in data from a clinic at Saudi Arabia.

作者信息

Awad Alsamghan S, Alshahrni Faisal Mubarak Mastour, Alhawyan Fatmah Salem, Ghazwani Eisa Yazeed, Alasmary Mohammed Yahia, Alshahrani Mohammed Yahia, Tobaiqi Muhammad Abubaker A, Alshahrani Sultan Saeed Mohammed, Alghamdi Shahad Saleh Abdullah, Bakri Semat Talal Hassan, Ayed Adil Ali

机构信息

Department of Family and Community Medicine, College of Medicine, King Khalid University, Abha, KSA-61421.

Family Medicine Consultants Armed Forces Hospitals Southern Region, Khamis Mushait, Aseer, Kingdom of Saudi Arabia.

出版信息

Bioinformation. 2021 Jan 31;17(1):119-125. doi: 10.6026/97320630017119. eCollection 2021.

Abstract

The clinical link among diabetes, obesity, and thyroid dysfunction is of interest. Hence, medical records of 601 patients with diabetes, obesity, and thyroid dysfunctions at the Abha Specialist Center and Military Diabetic Endocrine Center we used in this analysis. Approximately 28% of diabetic patients had thyroid dysfunction, and 12.4% were vitamin D deficient. The patients with thyroid dysfunction had significantly elevated triglyceride levels compared to the patients without thyroid dysfunction (173.6 vs. 128. p=0.009). Vitamin D deficient obese patients were significantly younger (33.99±10.69 vs. 43.68±14.42; p<0.001) and had significantly lower levels of HbA1c (5.73±1.16 vs. 6.83±2.08; p=0.014) and lower systolic BP (120.26±11.75 vs. 124.58±13.63; p=0.049) than non-vitamin D deficient obese patients. Vitamin D deficient thyroid patients had significantly lower diastolic BP (71.4±9.9 vs. 74.9±9.7; p=0.040) and higher HbA1c (8.7±3.6 vs. 6.4±1.7; p=0.003) in comparison to non-vitamin D deficient thyroid patients. Hence, analysis of metabolic disorders in these patients will help combat complications in these cases.

摘要

糖尿病、肥胖症和甲状腺功能障碍之间的临床联系备受关注。因此,我们在本次分析中使用了阿卜哈专科医院和军事糖尿病内分泌中心601例患有糖尿病、肥胖症和甲状腺功能障碍患者的病历。约28%的糖尿病患者存在甲状腺功能障碍,12.4%的患者维生素D缺乏。与无甲状腺功能障碍的患者相比,有甲状腺功能障碍的患者甘油三酯水平显著升高(173.6对128,p = 0.009)。维生素D缺乏的肥胖患者明显更年轻(33.99±10.69对43.68±14.42;p<0.001),糖化血红蛋白水平显著更低(5.73±1.16对6.83±2.08;p = 0.014),收缩压也更低(120.26±11.75对124.58±13.63;p = 0.049)。与非维生素D缺乏的甲状腺患者相比,维生素D缺乏的甲状腺患者舒张压显著更低(71.4±9.9对74.9±9.7;p = 0.040),糖化血红蛋白更高(8.7±3.6对6.4±1.7;p = 0.003)。因此,对这些患者的代谢紊乱进行分析将有助于对抗这些病例中的并发症。

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