Han Jong Chul, Cho Seok Ho, Sohn Dae Yong, Kee Changwon
Invest Ophthalmol Vis Sci. 2016 Feb;57(2):486-94. doi: 10.1167/iovs.15-17722.
We investigated the lamina cribrosa (LC) structural characteristics of myopic eyes with and without open-angle glaucoma (OAG) using enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT).
Defects in the LC in myopic eyes with and without OAG and normal eyes without myopia were evaluated using EDI SD-OCT. Among the two types of LC defects, disinsertion type and hole type, the associations among disinsertion type LC defects, myopia-related parameters of axial length (AL), maximal γ-zone peripapillary atrophy (PPA) length, disc tilt angle, and the presence of glaucoma were evaluated. In addition, disinsertion type LC defects were divided into two subtypes, complete detachment type and triangular wedge type, and the numbers of the subtypes in myopic eyes with and without OAG were investigated.
Defects in the LC were found more in myopic eyes with than without OAG (65.7% vs. 27.8%, P < 0.001). Of LC defects, disinsertion-type LC defects were found at the location of the γ-zone PPA (R = 0.71, P < 0.001), while the location of hole-type LC defects did not correlate with the location of the γ-zone PPA (R = 0.07, P = 0.73). Of disinsertion-type LC defects, complete detachment-type defects predominated in myopic eyes with OAG, while triangular wedge-type defects were the most common in myopic eyes without OAG (P < 0.001; P < 0.001, respectively). In multivariate logistic regression analysis, disinsertion-type LC defects in myopic eyes were associated with AL, maximal PPA length, and disc tilt angle, as well as the presence of glaucoma.
Given the strong correlation of disinsertion type LC defects with glaucoma and parameters related to myopia, such defects should be considered as biomarkers of glaucoma in myopic eyes.
我们使用增强深度成像光谱域光学相干断层扫描（EDI SD-OCT）研究了伴有和不伴有开角型青光眼（OAG）的近视眼中筛板（LC）的结构特征。
使用EDI SD-OCT评估伴有和不伴有OAG的近视眼中以及不伴有近视的正常眼中LC的缺陷。在两种类型的LC缺陷（插入缺失型和孔型）中，评估插入缺失型LC缺陷、眼轴长度（AL）、视盘周围萎缩（PPA）最大γ区长度、视盘倾斜角等近视相关参数与青光眼存在之间的关联。此外，将插入缺失型LC缺陷分为两个亚型，即完全脱离型和三角楔型，并研究伴有和不伴有OAG的近视眼中各亚型的数量。
伴有OAG的近视眼中LC缺陷的发现率高于不伴有OAG的近视眼（6５.７％对27.8％，P<0.001）。在LC缺陷中，插入缺失型LC缺陷位于γ区PPA处（R = 0.71，P<0.001），而孔型LC缺陷的位置与γ区PPA的位置无关（R = 0.07，P = 0.73）。在插入缺失型LC缺陷中，完全脱离型缺陷在伴有OAG的近视眼中占主导，而三角楔型缺陷在不伴有OAG的近视眼中最为常见（分别为P<0.001；P<0.001）。在多因素逻辑回归分析中，近视眼中插入缺失型LC缺陷与AL、最大PPA长度、视盘倾斜角以及青光眼的存在相关。
鉴于插入缺失型LC缺陷与青光眼以及近视相关参数之间的强相关性，此类缺陷应被视为近视眼中青光眼的生物标志物。
