Salvarani C, Rossi F, Macchioni P L, Baricchi R, Capozzoli N, Castellani S, Ghirelli L, Veneziani M, Scarti L, Portioli I
2a Divisione di Medicina (Unità Reumatologica) USL N9, Reggio Emilia; Italy.
Clin Exp Rheumatol. 1989 Jul-Aug;7(4):415-20.
A new case of association between Bartter's syndrome and chondrocalcinosis is reported. The patient was shown to have marked hypomagnesemia. Indomethacin and magnesium therapy was started and resulted in increased magnesemia, even if it did not reach normal levels. There was complete remission of articular symptoms and no progression on the radiological picture after 2 years of continuous magnesium and indomethacin therapy. The 7 available family members were studied to assess the possible presence of a familial form of chondrocalcinosis and/or hypomagnesemia. The literature is reviewed and reports of previously described associations between Bartter's syndrome and chondrocalcinosis are summarized. The possible role of hypomagnesemia in predisposing to deposition of calcium pyrophosphate dihydrate crystal in cartilagine is also discussed.
报告了一例巴特综合征与软骨钙质沉着症相关的新病例。该患者表现出明显的低镁血症。开始使用吲哚美辛和镁剂治疗，结果血镁升高，即便未达到正常水平。经过两年持续的镁剂和吲哚美辛治疗后，关节症状完全缓解，放射影像学表现无进展。对7名在世的家庭成员进行了研究，以评估软骨钙质沉着症和/或低镁血症家族性形式的可能存在情况。对文献进行了综述，并总结了先前描述的巴特综合征与软骨钙质沉着症之间关联的报告。还讨论了低镁血症在易患软骨中焦磷酸钙二水合物晶体沉积方面的可能作用。
