Vainshelboim Baruch, Fox Benjamin Daniel, Kramer Mordechai Reuven, Izhakian Shimon, Gershman Evgeni, Oliveira Jose
Pulmonary Institute, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel; Research Center in Physical Activity, Health and Leisure (CIAFEL), Faculty of Sport, University of Porto, Porto, Portugal.
Pulmonary Institute, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Arch Phys Med Rehabil. 2016 May;97(5):788-97. doi: 10.1016/j.apmr.2016.01.018. Epub 2016 Feb 8.
To examine the effect of participating in a 12-week supervised exercise training (ET) program on physical activity and body composition in patients with idiopathic pulmonary fibrosis (IPF).
Randomized controlled trial assessing physical activity and body composition at baseline, after 12-week intervention, and at 11 months follow-up.
Outpatient hospital.
Patients with IPF (N=34; mean age, 68±8y) recruited for this study; 32 patients completed the 12-week intervention (ET group: n=15; control group: n=17) and 28 patients (14 in each group) reassessed at 11-month follow-up from baseline.
Participation in a 12-week supervised ET program or regular medical treatment.
Changes in physical activity levels as measured by the International Physical Activity Questionnaire.
After the 12-week intervention, physical activity levels were significantly increased in the ET group whereas the control group showed a trend toward deterioration (median difference between the groups, 2164MET-min/wk [interquartile range, 1576MET-min/wk]; MET = metabolic equivalent; P<.001). Body composition was also significantly improved in the ET group, whereas the control group showed an opposite trend. At 11-month follow-up, no significant differences were observed between the 2 groups in all variables. The ET group lost most of the achieved improvements in the outcomes and returned to near baseline levels, whereas the control group showed a trend toward worsened outcomes.
Physical activity and body composition in patients with IPF were improved after a 12-week supervised ET program, although the benefits were not sustained at 11-month follow-up. These results may support the efficacy of participation in supervised ET to improve physical activity and body composition in patients with IPF; however, maintenance strategies are warranted to preserve the improved outcomes.
研究参加为期12周的有监督的运动训练（ET）项目对特发性肺纤维化（IPF）患者身体活动和身体成分的影响。
随机对照试验，在基线、12周干预后及11个月随访时评估身体活动和身体成分。
门诊医院。
招募参加本研究的IPF患者（N = 34；平均年龄，68±8岁）；32名患者完成了12周干预（ET组：n = 15；对照组：n = 17），28名患者（每组14名）在基线11个月随访时重新评估。
参加为期12周的有监督的ET项目或常规医学治疗。
通过国际身体活动问卷测量的身体活动水平变化。
12周干预后，ET组身体活动水平显著增加，而对照组有恶化趋势（两组间中位数差异，2164代谢当量分钟/周[四分位间距，1576代谢当量分钟/周]；代谢当量 = 代谢当量；P <.001）。ET组身体成分也显著改善，而对照组呈现相反趋势。在11个月随访时，两组在所有变量上均未观察到显著差异。ET组失去了大部分在结局方面取得的改善，恢复到接近基线水平，而对照组结局有恶化趋势。
IPF患者在参加为期12周的有监督的ET项目后，身体活动和身体成分得到改善，尽管在11个月随访时益处未持续。这些结果可能支持参加有监督的ET对改善IPF患者身体活动和身体成分的疗效；然而，需要维持策略来保持改善的结局。
