Erasme University Hospital, Chest Department, Université Libre Bruxelles, B-1060, Brussels, Belgium.
University Hospitals Leuven, Department of Respiratory Diseases, B-3000, Leuven, Belgium.
Respir Res. 2018 Sep 20;19(1):182. doi: 10.1186/s12931-018-0884-y.
Few data are available on the long-term effect of pulmonary rehabilitation (PR) and on long PR programs in interstitial lung diseases (ILD). We aimed to evaluate the effects of PR on exercise capacity (6-Minute Walking Distance, 6MWD; Peak Work Rate, W), quality of life (St George's Respiratory Questionnaire, SGRQ), quadriceps force (QF) and objectively measured physical activity in ILD after the 6-month PR-program and after 1 year.
60 patients (64 ± 11 years; 62% males; 23% with IPF) were randomly assigned to receive a 6 month-PR program or usual medical care.
Exercise capacity, quality of life and muscle force increased significantly after the program as compared to control (mean,95%CI[ll to ul]; 6MWD + 72,[36 to 108] m; W 19, [8 to 29]%pred; SGRQ - 12,[- 19 to - 6] points; QF 10, [1 to 18] %pred). The gain was sustained after 1 year (6MWD 73,[28 to 118] m; Wmax 23, [10 to 35]%pred; SGRQ - 11,[- 18 to - 4] points; QF 9.5, [1 to 18] %pred). Physical activity did not change.
PR improves exercise tolerance, health status and muscle force in ILD. The benefits are maintained at 1-year follow-up. The intervention did not change physical activity.
Clinicaltrials.gov NCT00882817 .
关于肺康复（PR）的长期效果以及间质性肺疾病（ILD）的长期 PR 方案，数据有限。我们旨在评估 PR 对 ILD 患者 6 个月 PR 项目结束后和 1 年后的运动能力（6 分钟步行距离，6MWD；峰值工作率，W）、生活质量（圣乔治呼吸问卷，SGRQ）、股四头肌力量（QF）和客观测量的体力活动的影响。
60 名患者（64±11 岁；62%为男性；23%为特发性肺纤维化）被随机分配接受 6 个月的 PR 项目或常规医疗护理。
与对照组相比，运动能力、生活质量和肌肉力量在项目结束后显著增加（平均值，95%CI[下限到上限]；6MWD 增加了 72 米，[36 到 108]米；W 增加了 19%，[8 到 29]%预测值；SGRQ 减少了 12 分，[-19 到-6]分；QF 增加了 10%，[1 到 18]%预测值）。1 年后，这种改善仍能维持（6MWD 增加了 73 米，[28 到 118]米；Wmax 增加了 23%，[10 到 35]%预测值；SGRQ 减少了 11 分，[-18 到-4]分；QF 增加了 9.5%，[1 到 18]%预测值）。体力活动没有变化。
PR 可改善 ILD 患者的运动耐量、健康状况和肌肉力量。在 1 年的随访中，这些益处得以维持。干预措施并未改变体力活动。
Clinicaltrials.gov NCT00882817。
