Lawrence W, Neifeld J P
Division of Surgical Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond.
Curr Probl Surg. 1989 Nov;26(11):753-827. doi: 10.1016/0011-3840(89)90036-1.
Soft tissue sarcomas in infants and children differ from those in adults in clinical presentation, histology, and response to therapy. For rhabdomyosarcoma, the most common sarcoma in children, each primary site has special characteristics that affect both treatment programs and survival rates. Some results are so good, from the standpoint of survival data, that studies are now in progress to evaluate means of reducing treatment morbidity. Other ongoing studies focus on improved protocols for metastatic or recurrent rhabdomyosarcoma. Results thus far in the IRS trials have proven the value of cooperative clinical trials in the management of patients with this disease.
婴幼儿软组织肉瘤在临床表现、组织学及对治疗的反应方面与成人软组织肉瘤有所不同。横纹肌肉瘤是儿童最常见的肉瘤，每个原发部位都有其特殊特征，这些特征会影响治疗方案和生存率。从生存数据来看，有些结果非常理想，以至于目前正在进行研究以评估降低治疗并发症的方法。其他正在进行的研究则聚焦于改善转移性或复发性横纹肌肉瘤的治疗方案。迄今为止，IRS试验的结果已证明了合作性临床试验在该疾病患者管理中的价值。
