Ahmed Tarek A, Aljaeid Bader M
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Drug Des Devel Ther. 2016 Jan 28;10:483-507. doi: 10.2147/DDDT.S99651. eCollection 2016.
Naturally occurring polymers, particularly of the polysaccharide type, have been used pharmaceutically for the delivery of a wide variety of therapeutic agents. Chitosan, the second abundant naturally occurring polysaccharide next to cellulose, is a biocompatible and biodegradable mucoadhesive polymer that has been extensively used in the preparation of micro-as well as nanoparticles. The prepared particles have been exploited as a potential carrier for different therapeutic agents such as peptides, proteins, vaccines, DNA, and drugs for parenteral and nonparenteral administration. Therapeutic agent-loaded chitosan micro- or nanoparticles were found to be more stable, permeable, and bioactive. In this review, we are highlighting the different methods of preparation and characterization of chitosan micro- and nanoparticles, while reviewing the pharmaceutical applications of these particles in drug delivery. Moreover, the roles of chitosan derivatives and chitosan metal nanoparticles in drug delivery have been illustrated.
天然存在的聚合物，特别是多糖类聚合物，已被用于药学领域以递送多种治疗剂。壳聚糖是仅次于纤维素的第二丰富的天然存在的多糖，是一种生物相容性和可生物降解的粘膜粘附聚合物，已广泛用于制备微米级和纳米级颗粒。所制备的颗粒已被用作不同治疗剂的潜在载体，如肽、蛋白质、疫苗、DNA以及用于肠胃外和非肠胃外给药的药物。载有治疗剂的壳聚糖微米级或纳米级颗粒被发现更稳定、更具渗透性且具有生物活性。在本综述中，我们重点介绍壳聚糖微米级和纳米级颗粒的不同制备方法和表征，同时回顾这些颗粒在药物递送中的药学应用。此外，还阐述了壳聚糖衍生物和壳聚糖金属纳米颗粒在药物递送中的作用。
