八聚体转录因子4与胃癌进展及预后相关。
Oct-4 is associated with gastric cancer progression and prognosis.
作者信息
Jiang Wen-Li, Zhang Peng-Fei, Li Guo-Feng, Dong Jian-Hua, Wang Xue-Song, Wang Yuan-Yu
机构信息
Department of Surgery, Juxian People's Hospital, Rizhao People's Hospital of Traditional Chinese Medicine, Rizhao, People's Republic of China.
Department of Surgery, Rizhao People's Hospital of Traditional Chinese Medicine, Rizhao, People's Republic of China.
出版信息
Onco Targets Ther. 2016 Jan 27;9:517-22. doi: 10.2147/OTT.S90031. eCollection 2016.
AIM
To investigate the clinical significance of Oct-4 in the development and progression of gastric cancer.
METHODS
Immunohistochemistry was used to analyze Oct-4 expression in 412 gastric cancer cases. Oct-4 protein levels were upregulated in gastric cancer tissues compared with adjacent noncancerous tissues.
RESULTS
Positive expression of Oct-4 correlated with age, depth of invasion, Lauren classification, lymph node metastasis, distant metastasis, and TNM stage. In stages I, II, and III, the 5-year survival rate of patients with high expression of Oct-4 was significantly lower than that in patients with low expression of Oct-4. In stage IV, Oct-4 expression did not correlate with the 5-year survival rate. Furthermore, multivariate analysis suggested that the depth of invasion, lymph node metastasis, distant metastasis, TNM stage, and upregulation of Oct-4 were independent prognostic factors of gastric cancer.
CONCLUSION
Oct-4 protein is a useful marker in predicting tumor progression and prognosis.
目的
探讨Oct-4在胃癌发生发展及进展中的临床意义。
方法
采用免疫组织化学法分析412例胃癌病例中Oct-4的表达情况。与相邻的非癌组织相比，胃癌组织中Oct-4蛋白水平上调。
结果
Oct-4的阳性表达与年龄、浸润深度、Lauren分型、淋巴结转移、远处转移及TNM分期相关。在Ⅰ、Ⅱ和Ⅲ期，Oct-4高表达患者的5年生存率显著低于Oct-4低表达患者。在Ⅳ期，Oct-4表达与5年生存率无关。此外，多因素分析表明浸润深度、淋巴结转移、远处转移、TNM分期及Oct-4上调是胃癌的独立预后因素。
结论
Oct-4蛋白是预测肿瘤进展和预后的有用标志物。
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