Liu Nannan, Fei Xiawei, Shen Yi, Shi Weifeng, Ma Jinhong
Department of Clinical Laboratory, The Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, People's Republic of China.
Department of Urology Surgery, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.
Onco Targets Ther. 2016 Jan 28;9:579-86. doi: 10.2147/OTT.S95658. eCollection 2016.
The relationship between XRCC1 polymorphisms and bladder cancer has been widely studied. Here, our meta-analysis was conducted to evaluate the correlations between common genetic polymorphisms in XRCC1 and susceptibility to bladder cancer. In order to derive a more precise estimation of the association, 27 clinical case-control studies (which met all the inclusion criteria) were included in this meta-analysis. A total of 8,539 cancer cases and 10,750 controls were involved in this meta-analysis. Overall, no significant association was detected in allelic model (A allele vs T allele odds ratio [OR] =0.87, 95% confidence interval [CI], 0.71-1.06), homozygote comparison (AA vs GG OR =1.12, 95% CI, 0.68-1.85), heterozygote comparison (AT vs TT OR =1.01, 95% CI, 0.81-1.26), dominant model (AA + AG vs GG OR =0.93, 95% CI, 0.85-1.02), and recessive model (AA vs AG + GG OR =1.01, 95% CI, 0.88-1.15), but a moderately significant association was found for AG vs GG (OR =0.241, 95% CI =0.17-0.35). Subgroup analysis based on ethnicity. Ethnicity analysis suggested that genetic polymorphisms in XRCC1 were not correlated with increased bladder cancer risk among Asians (all P>0.05). Therefore, we concluded that XRCC1 genetic polymorphism may not contribute to bladder cancer susceptibility in the present meta-analysis, and further well-designed studies with a large sample size are warranted to validate our conclusion.
XRCC1基因多态性与膀胱癌的关系已得到广泛研究。在此，我们进行了一项荟萃分析，以评估XRCC1常见基因多态性与膀胱癌易感性之间的相关性。为了更精确地估计这种关联，本荟萃分析纳入了27项临床病例对照研究（均符合所有纳入标准）。该荟萃分析共涉及8539例癌症病例和10750例对照。总体而言，在等位基因模型（A等位基因与T等位基因比值比[OR]=0.87，95%置信区间[CI]，0.71 - 1.06）、纯合子比较（AA与GG，OR = 1.12，95% CI，0.68 - 1.85）、杂合子比较（AT与TT，OR = 1.01，95% CI，0.81 - 1.26）、显性模型（AA + AG与GG，OR = 0.93，95% CI，0.85 - 1.02）和隐性模型（AA与AG + GG，OR = 1.01，95% CI，0.88 - 1.15）中均未检测到显著关联，但在AG与GG比较中发现了中度显著关联（OR = 0.241，95% CI = 0.17 - 0.35）。基于种族的亚组分析。种族分析表明，XRCC1基因多态性与亚洲人膀胱癌风险增加无关（所有P > 0.05）。因此，我们得出结论，在本荟萃分析中，XRCC1基因多态性可能与膀胱癌易感性无关，需要进一步开展设计良好的大样本研究来验证我们的结论。
