Jafari Nedooshan Jamal, Forat Yazdi Mohammad, Neamatzadeh Hossein, Zare Shehneh Masoud, Kargar Saeed, Seddighi Niloofar
Department of General Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Email:
Asian Pac J Cancer Prev. 2017 Jan 1;18(1):263-270. doi: 10.22034/APJCP.2017.18.1.263.
Background: A number of case-control studies have evaluated associations between the X-ray cross complementary group 1 protein (XRCC1) gene rs1799782 (Arg194Trp), rs25487 (Arg399Gln) and rs25489 (Arg280His) polymorphisms and thyroid cancer (TC) risk, but the results remain inconclusive. Materials and Methods: A systematic literature search was performed using PubMed and Google Scholar Search. According to defined criteria data were extracted and pooled odds ratios with 95% confidence intervals were calculated under five genetic models. Results: A total of 8 studies with 1,672 cases and 2,805 controls for the rs1799782 polymorphism, 14 studies with 2,506 cases and 5,180 controls for the rs25487 polymorphism, and 11 studies with 2,197 cases and 4,761 controls for the rs25489 polymorphism were included in this meta-analysis. Overall, there was a statistical association between XRCC1 rs1799782 polymorphism and TC risk with the homozygote genetic model (TT vs. CC: OR = 1.815, 95% CI = 1.115-2.953, p= 0.016) and the recessive genetic model (TT vs. TC+CC: OR = 1.854, 95% CI = 1.433-2.399, p= <0.001). In the subgroup analysis by ethnicity, significantly increased TC risk was observed only in Asians under the recessive model (TT vs. TC+CC: OR = 1.816, 95% CI = 1.398-2.358, p= <0.001). In addition, there was no positive association between XRCC1 rs25487 and rs25489 polymorphisms and risk of TC. However, there was a significant association between XRCC1 rs25487 polymorphism risk of TC among Caucasians with allele genetic comparison (A vs. G: OR= 0.882, 95% CI = 0.794-0.979, p= 0.136) and dominant genetic comparison (AA+AG vs. GG: OR=0.838, 95% CI = 0.728-0.965, p= 0.014). Conclusions: The results of our meta-analysis suggest an increased risk of TC with the XRCC1 rs1799782 and rs25487 polymorphisms. However, the XRCC1 rs25489 polymorphism appeared to be without influence.
多项病例对照研究评估了X射线修复交叉互补基因1蛋白（XRCC1）基因rs1799782（Arg194Trp）、rs25487（Arg399Gln）和rs25489（Arg280His）多态性与甲状腺癌（TC）风险之间的关联，但结果仍无定论。
使用PubMed和谷歌学术搜索进行系统的文献检索。根据既定标准提取数据，并在五种遗传模型下计算合并优势比及95%置信区间。
本荟萃分析纳入了8项研究，涉及rs1799782多态性的1672例病例和2805例对照；14项研究，涉及rs25487多态性的2506例病例和5180例对照；11项研究，涉及rs25489多态性的2197例病例和4761例对照。总体而言，XRCC1 rs1799782多态性与TC风险之间在纯合子遗传模型（TT与CC：OR = 1.815，95%CI = 1.115 - 2.953，p = 0.016）和隐性遗传模型（TT与TC + CC：OR = 1.854，95%CI = 1.433 - 2.399，p = <0.001）下存在统计学关联。在按种族进行的亚组分析中，仅在亚洲人隐性模型下观察到TC风险显著增加（TT与TC + CC：OR = 1.816，95%CI = 1.398 - 2.358，p = <0.001）。此外，XRCC1 rs25487和rs25489多态性与TC风险之间无正相关。然而，在白种人中，XRCC1 rs25487多态性与TC风险在等位基因遗传比较（A与G：OR = 0.882，95%CI = 0.794 - 0.979，p = 0.136）和显性遗传比较（AA + AG与GG：OR = 0.838，95%CI = 0.728 - 0.965，p = 0.014）下存在显著关联。
我们的荟萃分析结果表明，XRCC1 rs1799782和rs25487多态性会增加TC风险。然而，XRCC1 rs25489多态性似乎没有影响。
