2013年转诊至德黑兰伊玛目霍梅尼医院行为疾病咨询中心的艾滋病病毒/艾滋病合并隐孢子虫病患者的临床特征

Clinical Characteristic of the HIV/AIDS Patients with Cryptosporidiosis Referring to Behavioral Diseases Consultation Center, Imam Khomeini Hospital, Tehran in 2013.

作者信息

Gholami Rashid, Gholami Shirzad, Emadi-Kouchak Hamid, Abdollahi Alireza, Shahriari Mona

机构信息

Dept. of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran.

Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

出版信息

Iran J Pathol. 2016 Winter;11(1):27-34.

PMID:26870140

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4749192/

Abstract

BACKGROUND

Cryptosporidium is known as an opportunist disease-causing agent in man in recent decades. It causes diarrhea and intestinal disorders in the immune deficit and immune competent individuals. This study was aimed to investigate the clinical characteristics of HIV/AIDS patients with cryptosporidiosis infection.

METHODS

This cross-sectional descriptive study was performed on 53 HIV/AIDS patients referred to the Behavior Disease Consultation Center of Imam Khomeini Hospital in Tehran, Iran in 2013. First, the patients were studied clinically and the context data were recorded in a questionnaire for parasitological examination and referred to the laboratory for eosinophil count, and CD4 count per ml of blood.

RESULTS

Cryptosporidiosis was observed in 4 (7.6%) of the total 53 HIV/AIDS patients. The highest prevalence of infection was observed in the age range of 30-39 yr. It was observed in different sexes as 5.7% of male and 1.9% of female, but statistically was insignificant (P=0.163).75% of patients had no intestinal symptom, 11.4% with acute diarrhea and 3.8% with chronic diarrhea. Cryptosporidiosis cases were observed in 5.7% of patients without intestinal symptom.

CONCLUSION

Practitioners in the clinical examination for the detection of the opportunistic intestinal protozoan infection should use clinical and paraclinical characteristics of the HIV/AIDS patients for the diagnostic of Cryptosporidium and other opportunistic parasitic diseases.

摘要

背景

近几十年来，隐孢子虫被认为是人类的一种机会性致病原。它在免疫功能缺陷和免疫功能正常的个体中引起腹泻和肠道紊乱。本研究旨在调查感染隐孢子虫病的艾滋病毒/艾滋病患者的临床特征。

方法

2013年，对转诊至伊朗德黑兰伊玛目霍梅尼医院行为疾病咨询中心的53例艾滋病毒/艾滋病患者进行了这项横断面描述性研究。首先，对患者进行临床研究，并将背景数据记录在问卷中，用于寄生虫学检查，并转诊至实验室进行嗜酸性粒细胞计数和每毫升血液中的CD4计数。

结果

在53例艾滋病毒/艾滋病患者中，有4例（7.6%）检测到隐孢子虫病。感染率最高的年龄段为30 - 39岁。不同性别的感染率分别为男性5.7%，女性1.9%，但差异无统计学意义（P = 0.163）。75%的患者无肠道症状，11.4%有急性腹泻，3.8%有慢性腹泻。在无肠道症状的患者中，隐孢子虫病的检出率为5.7%。