Mohamed Shaaban K, Akkurt Mehmet, Jasinski Jerry P, Abdelhamid Antar A, Tamam Asmaa H, Albayati Mustafa R
Chemistry and Environmental Division, Manchester Metropolitan University, Manchester M1 5GD, England; Chemistry Department, Faculty of Science, Minia University, 61519 El-Minia, Egypt.
Department of Physics, Faculty of Sciences, Erciyes University, 38039 Kayseri, Turkey.
Acta Crystallogr E Crystallogr Commun. 2015 Nov 25;71(Pt 12):o989-90. doi: 10.1107/S2056989015022240. eCollection 2015 Dec 1.
In the title compound, C23H24BrNO5, the central 1,4-di-hydro-pyridine ring of the 1,2,3,4,5,6,7,8,9,10-deca-hydro-acridine ring system adopts a half-chair conformation. The two cyclo-hexene rings fused to the central ring both have a twisted-boat conformation. The mean planes of the bromo-hydroxy-phenyl ring and the major and minor components of the disordered ethyl amino-acetate moiety make dihedral angles of 78.99 (12), 85.9 (2) and 88.3 (9)°, respectively, with the 1,4-di-hydro-pyridine ring. The terminal ethyl group of the ethyl amino-acetate moiety is disordered over two sets of sites with refined occupancies of 0.768 (17) and 0.232 (17). The mol-ecular conformation is stabilized by an intra-molecular O-H⋯O hydrogen bond, forming an S(8) ring motif. In the crystal, C-H⋯O hydrogen bonds connect the mol-ecules into layers parallel to (001), enclosing R 1 (2)(7) ring motifs.
在标题化合物C₂₃H₂₄BrNO₅中，1,2,3,4,5,6,7,8,9,10-十氢吖啶环系的中心1,4-二氢吡啶环呈半椅构象。与中心环稠合的两个环己烯环均呈扭船构象。溴代羟基苯基环以及无序的乙氨基乙酸酯部分的主要和次要组分的平均平面与1,4-二氢吡啶环分别形成78.99 (12)°、85.9 (2)°和88.3 (9)°的二面角。乙氨基乙酸酯部分的末端乙基在两组位置上无序，精修占有率分别为0.768 (17)和0.232 (17)。分子构象通过分子内O—H⋯O氢键得以稳定，形成S(8)环模式。在晶体中，C—H⋯O氢键将分子连接成平行于(001)的层，围成R 1 (2)(7)环模式。
