Abdelhamid Antar A, Mohamed Shaaban K, Simpson Jim
Chemistry Department, Faculty of Science, Sohag University, 82524 Sohag, Egypt.
Chemistry and Environmental Division, Manchester Metropolitan University, Manchester M1 5GD, England.
Acta Crystallogr Sect E Struct Rep Online. 2014 Jul 19;70(Pt 8):44-7. doi: 10.1107/S1600536814009556. eCollection 2014 Aug 1.
The title compound C25H29BrClNO4, comprises a 3,3,6,6-tetra-methyl-tetra-hydro-acridine-1,8-dione ring system that carries a hy-droxy-ethyl substituent on the acridine N atom and a 3-bromo-5-chloro-2-hy-droxy-phenyl ring on the central methine C atom of the di-hydro-pyridine ring. The benzene ring is inclined to the acridine ring system at an angle of 89.84 (6)° and this conformation is stabilized by an intra-molecular O-H⋯O hydrogen bond between the hy-droxy substituent on the benzene ring and one of the carbonyl groups of the acridinedione unit. In the crystal, O-H⋯O, C-H⋯O and C-H⋯Br hydrogen bonds combine to stack mol-ecules in inter-connected columns propagating along the a-axis direction.
标题化合物C25H29BrClNO4包含一个3,3,6,6-四甲基-四氢吖啶-1,8-二酮环系,该环系在吖啶N原子上带有一个羟乙基取代基,在二氢吡啶环的中心次甲基C原子上带有一个3-溴-5-氯-2-羟基苯基环。苯环与吖啶环系呈89.84 (6)°的夹角,这种构象通过苯环上的羟基取代基与吖啶二酮单元的一个羰基之间的分子内O-H⋯O氢键得以稳定。在晶体中,O-H⋯O、C-H⋯O和C-H⋯Br氢键相结合,使分子沿a轴方向堆积成相互连接的柱体。